Registration Dossier
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EC number: 231-102-5 | CAS number: 7439-93-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Short-term toxicity test in daphnia with
lithium is not available. Consequently, read-across was applied using
study results obtained from lithium hydroxide. Lithium hydroxide (55.2
%) was tested for short term aquatic toxicity in daphnia in an 48-hour
static test according to EU Method C.2 and OECD Guideline 202. Without
pH-adjustment the 48 hour EC 50-value was 19.1 mg/L. With pH-adjustment
the 48-hour EC 50-value 34.3 mg/L for Lithium hydroxide anhydrous.
Based on a read-across approach the calculated EC50 value (with
pH-adjustment) for lithium metal was 10 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 10 mg/L
Additional information
Short-term toxicity test in daphnia with lithium is not available. Consequently, read-across was applied using study results obtained from lithium hydroxide. The acute toxicity of the test substance lithium hydroxide (55.2 %) to daphnia magna was determined in a 48-hour static test according to the EU method Annex Part C.2 and the OECD Guideline No. 202. The nominal concentrations tested were 4.6, 10, 21, 46 and 100 mg test substance/L, and in parallel a control. At one series of test media the pH was adjusted to approximately pH 8 by HCl, at the other series not. This allowed to differentiate if a toxic effect is caused due to a pH-effect of the test substance with a strong basic pH, or if it is a real toxic effect of lithium(-hydroxide). The analytical determined test substance concentrations in the analysed test media varied in the range from 93.5 % to 103.2 % of the nominal values. In the test media the test substance concentrations were constant during the test period of 48 hours. Therefore, all reported biological results are related to the nominal concentrations of the test substance. Without pH-adjustment the 48 hour EC50-value was 19.1 mg/L and with pH-adjustment the 48-hour EC50-value 34.3 mg/L for lithium hydroxide anhydrous. It is obvious that lithium hydroxide monohydrate was the test material (due to the indicated purity: 55.2%) but the study results and study title refer to lithium hydroxide anhydrous.
Based on a read-across approach the calculated EC50 value (with pH-adjustment) for lithium metal was 10 mg/L.
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