Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Information is available from reliable studies for all the required in vitro endpoints. There are two bacterial mutagenicity studies available. The key study was chosen because effects were seen in the study. The results of all the other studies were in agreement. In addition, there is an in vivo mouse micronucleus study on the related substance, trimethoxyvinylsilane, which is considered a close structural analogue of dichloro(methyl)vinylsilane.

Short description of key information:
In vitro:
Gene mutation (Bacterial reverse mutation assay / Ames test): positive with hamster liver activation in strain TA1535 only. No increase in revertants when rat liver S9 was used as the activation system (similar to OECD TG 471)
Cytogenicity in mammalian cells: negative with and without activation in cultured human lymphocytes (OECD TG 473)
Mutagenicity in mammalian cells: negative in L5178Y mouse lymphoma cells (similar to OECD TG 476)
in vivo
read-across from analogous substance CAS 2768-02-7: negative in mouse micronucleus test (US EPA guideline test, similar to OECD TG 474)

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The available information for the substance indicates that when tested in vitro, dichloro(methyl)(vinyl)silane (CAS number 124 -70 -9) induces mutations in one bacterial strain (Salmonella typhimurium TA 1535) in the presence of activation derived from hamster liver but not when activation from rat livers was used. This result was not confirmed when the substance was tested in mammalian cells, nor did the substance induce chromosome aberrations in mammalian cells. In addition, an in vivo micronucleus study on the related substance, trimethoxyvinylsilane, did not show evidence of genetic toxicity. Therefore it is considered that classification for mutagenicity is not required.