Registration Dossier
Registration Dossier
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EC number: 222-583-2 | CAS number: 3542-36-7
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Study period:
- 2006, 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline evaluation, medical standard procedure
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 011
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 010
- Reference Type:
- publication
- Title:
- Acute toxic effects of dioctyltin on immune system of rats
- Author:
- Kishi et al.
- Year:
- 2 006
- Bibliographic source:
- Environmental and Pharmacology 22 (2006) 240-247
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 431
- Deviations:
- not applicable
- Principles of method if other than guideline:
- see free text
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Dioctyltin dichloride
- IUPAC Name:
- Dioctyltin dichloride
- Test material form:
- other: see free text
- Details on test material:
- -
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: see free text
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: see free text
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- other: see free text
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- see free text
- Frequency of treatment:
- see free text
- Duration of test:
- see free text
- No. of animals per sex per dose:
- see free text
- Control animals:
- other: see free text
Results and discussion
Effect levels
- Dose descriptor:
- other: see free text
- Sex:
- male/female
- Basis for effect level:
- other: see free text
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Applicant's summary and conclusion
- Conclusions:
- Tonk and Menke dedermined no adverse effect for reproduction and develomental in rat caused by Dioctyltin dichloride. The adverse effect in immune system is considered an acute effect, this is shown by Kishi. The adverse effect is completly reversible withhin a recovery time.
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