Dichlorodioctylstannane

Endpoint summary

Additional information

Acute

Fish:

In a 96-h acute toxicity study, Zebra fish (Brachydanio rerio) were exposed to dioctyltin dichloride in a limit lest at a mean-measued concentration of 0.24 ± 0.14 mg/L under semi-static conditions. No mortality was seen during the test so therefore the 96 hour NOEC is ≥ 0.24 mg/L and the 96 hour LC50 > 0.24 mg/L.

Daphnia:

In a 48 hour acute toxicity study, the cultures ofDaphnia magna,were exposed to Dioctyltin dichloride at a mean measure concentration of 0.28 mg/L in a limit test, under semi-static conditions in accordance with the OECD 202 guideline. The NOEC and EC50 were both found to be > 0.28 mg/L, exceeding the limit of solubility in water of the test substance. No immobility was observed in the test or control vessels.

Algae:

The toxicity of Dioctyltin dichloride (CAS# 3459 -36 -7) to the fresh water green alga Scenedesmus subspicatus was determined in a 72-h growth inhibition test according to the OECD 201 test guideline. Nominal test concentrations of 10, 18, 32, 58 100 % of a 100 mg/L saturated stock solution were tested. No effect on cell growth was observed from any of the test solutions.

The EC50 value was considered to be > 0.0017 mg/L.

Chronic

Daphnia:

A study was performed to assess the effect of dioctyltin on the mortality and reproduction to Daphnia magna over a 21-day period. The method followed that described in the OECD Guidelines for Testing of Chemicals No 202. The test was preformed under semi static conditions using triethylene glycol and a vehicle.

The 21 day NOEC of DOTC in Daphnia magna for survival was 0.41 mg/L, the LOEC was 0.87 mg/L. The reproduction in any test solution was not statistically different from the control. Therefore, the 21 day NOEC for reproduction was ≥ 0.87 mg/L.

C&L

Based on the available data no classification can be assigned as all of the LC/EC50 values are greater than values. The substance was tested at the limit of solubility in the studies due to the insolubility of the substance, and at these levels no effects were seen.

The test substance hydrolyses rapidly and is not readily biodegrable due to it's highly toxic effect on microorganisms.

However, the substance is classified under Annex I of the first ATP of regulation (EC) No 1272/2008 and directive 67/548/EEC as H412 Harmful to aquatic life with long lasting effects (Aquatic chronic 3) and R53 (May cause long-term adverse effects in the aquatic environment) respectively, the data available concerning aquatic toxicity is not sufficient to imply that further classification is needed.