Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-583-2 | CAS number: 3542-36-7
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
No determination was performed by the flask method, designed to be compatible with Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. The test item was concluded to hydrolyse fully within 10 minutes of contact with water. Thus, it was considered that the water solubility test was not feasible as the guideline states that the test is not applicable to unstable substances.
Key value for chemical safety assessment
Additional information
A data waiver was used to fulfil this endpoint based on the information given in the Butler & White (2010) study. A reliability rating of 1 was assigned to this study, according to the criteria of Klimisch, 1997 as the study was conducted to recognised guidelines, however due to the nature of the substance, a water solubility could not be obtained.
Supporting information is also available for this endpoint:
In the Ventur, 1989 study the water solubility was determined to be 1.6 ± 0.1 mg/l. However this was using the same method as the above study (OECD 105) and so a reliability rating of 3 was assigned to this study, according to the criteria of Klimisch, 1997 as the nature of the substance would indicate that the study is not technically feasible.
In a supporting study (Waterson et al, 1994) the water solubility was determined to be 0.02 - 0.06 mg/L.
A reliability rating of 4 was assigned, according to the criteria of Klimisch, 1997 as the value was obtained from government report however specifics of test were not reported.
In a supporting study (Steinhäuser et al, 1985) the water solubility was determined to be 0.02 mg/L.
A reliability rating of 4 was assigned, according to the criteria of Klimisch, 1997 as value obtained from scientific literature; specifics of test not reported. GLP status and purity unknown.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
