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Short-term toxicity to fish

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Description of key information

LC50 (96 h) > 0.52 mg/L (measured mean concentration) for Oryzias latipes (OECD 203)
LC50 (96 h) > 1000 mg/L (nominal concentration) for Lepomis macrochirus (EPA OPPTS 850.1075)
LC50 (48 h) = 1666 mg/L (nominal concentration) for Leuciscus idus (DIN 38412/15)

Key value for chemical safety assessment

Additional information

Three studies evaluating the acute toxicity of methyl laurate (CAS No. 111-82-0) to fish are available. The key study (Japanese Ministry of the Environment, 2004) was conducted according to OECD Guideline 203 under GLP conditions. Fish (Oryzias latipes) were exposed to the test substance for 120 hours within a flow-through water regime at a nominal concentration of 1 mg/L (nominal, limit test). After the exposure period, no mortality was observed in treatment or control vessels and therefore the 96h (and 120h) LC50 was determined to be > 0.52 mg/L (measured mean concentration). An additional study, performed using a methodology similar to Guideline EPA OPPTS 850.1075 was conducted, at concentrations ranging from 180 to 1000 mg/L. No mortality of Lepomis macrochirusafter 96 hours exposure to the test substance was observed, being the LC50 (96 h) > 1000 mg/L (Calmbacher, 1977). Finally, Richterich and Mühlberg (2001) tested the effect of methyl laurate inLeuciscus idusfor 48 hours (according to German method DIN 38412/15), at nominal concentrations ranging from 1 to 10000 mg/L. Mortality was observed at the highest concentrations tested (3000 and 10000 mg/L), however, since these effects are well over the water solubility of the substance probably are due to physical effects rather than to toxicity.