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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
N/A to 1968-04-18
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP study similar to OECD 423 with sufficient documentation on methods and results to evaluate data.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968
Report Date:
1968

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Deviations:
not specified
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): thermal phosphoric acid
- Analytical purity: 75.4%

Test animals

Species:
rat
Strain:
other: SPF-Wister K
Sex:
female
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 80-134 g
- Fasting period before study: 12 hrs
- Diet: After application rats received the standard-ALTROMIN R feed
- Water: tap water



Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 10% aqueous solution
- Amount of vehicle (if gavage): 0.8 to 5.0- mL/100g-bw






Doses:
0.8, 1.25, 2.0, 3.2, and 5.0 mL per 100 g body weight
No. of animals per sex per dose:
10 female rats
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
1.7 other: mL/100 g body weight
Mortality:
In the 0.8 mL/100 g-bw dose group there was no mortalities and in the 1.25 mL/100 g-bw group 2 of the 10 animals died. In the 2.00 mL/100 g-bw dose group 8 of the 10 animals died and in the 3.20 mL/100 g-bw and 5.0 mL/100 g-bw dose group all 10 of the animals died.
Clinical signs:
The animals died unbalanced, lying on tummy or flank, with breathing difficulties and cramps within 30 minutes to 24 hours after application.
Gross pathology:
The necropsy of the animals showed macroscopic strong chemical burns on the mucous membrane of the stomach.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 for a 10% solution of 75.4% thermal phosphoric acid in rats was determined to be 1.70 ml/100 g body weight (approximately 2600 mg/kg bw).