3,7-dimethyloctan-3-ol

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data available as short summary from a secondary source beeing cited in a peer-reviewed publication

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Report on human maximization studies.

Author:

Epstein WL

Year:

1976

Bibliographic source:

RIFM FEMA Database, Location 1796

Report date:

1976

Reference 2

Reference Type:

secondary source

Title:

Report on human maximization studies.

Author:

Epstein WL

Year:

1976

Bibliographic source:

cited in: Opdyke DLJ, Food Cosmet. Toxicol., Vol 17, p. 909, 1979

Reference 3

Reference Type:

publication

Title:

Fragrance material review on tetrahydrolinalool

Author:

Lapczynski et al.

Year:

2008

Bibliographic source:

Food Chem. Toxicol.; 46; 286-288

Materials and methods

Study type:

study with volunteers

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Human maximization test was conducted on 32 healthy volunteers

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethyloctan-3-ol

EC Number:

201-133-9

EC Name:

3,7-dimethyloctan-3-ol

Cas Number:

78-69-3

Molecular formula:

C10H22O

IUPAC Name:

3,7-dimethyloctan-3-ol

Method

Subjects:

- Number of subjects exposed: 32
- Sex: unspecified
- Age: 18 +

Clinical history:

- Other: stated healthy, no further information provided

Controls:

Vehicle (petrolatum) and SLS controls were placed on the left and on the right.

Route of administration:

dermal

Details on study design:

TYPE OF TEST(S) USED: patch test (epicutaneous test)
Human maximization test

ADMINISTRATION
- Type of application: occlusive, 5 alternate-day 48-hour periods
- Vehicle / solvent: Petrolatum
- Concentrations: 4%
- Dermal load: 2760 µg/cm2
- Testing/scoring schedule: Following a 10- to 14-day rest period, a challenge patch of the test material was applied to a fresh site for 48 hours under occlusion
- Other: The patch sites were pretreated for 24 hours with 5% aqueous SLS under occlusion for the initial patch only. Prior to the challenge, 5% SLS was applied to the test sites for 30 minutes under occlusion on the left side of the back, while the test materials were applied without SLS treatment on the right side.

Results and discussion

Results of examinations:

SYMPTOMS
- Frequency, level, duration of symptoms observed: no effects reported

Any other information on results incl. tables

Pretest: No dermal irritation was observed.

Main test: No sensitization reactions were observed