Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via inhalation route
Dose descriptor:
NOAEC
2 213.5 mg/m³
Additional information

In the absence of measured data for chlorodimethylsilane, it is considered appropriate to use this result in support of the reproductive toxicity endpoint for chlorodimethylsilane as the registered substance is hydrolysed very rapidly in the presence of moisture to dimethylsilanol and hydrogen chloride. The tested substance, trimethylsilanol is closely related to dimethylsilanol (replacement of -H with -CH3) and both substances have similar physicochemical properties (high water solubility and low log Kow), therefore the toxicological properties are expected to be similar.


Short description of key information:
In the key repeated inhalation study (Fleeman, 2008; an OECD 422 study) read across from trimethylsilanol, there were no adverse effects on reproduction parameters. Therefore, under the conditions of this screening study, an exposure level of 600 ppm (2213.5 mg/m3) was considered to be the NOAEL for trimethylsilanol.

Effects on developmental toxicity

Description of key information
In the key repeated inhalation study (Fleeman, 2008; an OECD 422 study) read across from trimethylsilanol, there were no adverse effects on developmental parameters. Therefore, under the conditions of this screening study, an exposure level of 600 ppm (2213.5 mg/m3) was considered to be the NOAEL for trimethylsilanol. 
Effect on developmental toxicity: via inhalation route
Dose descriptor:
NOAEC
2 213.5 mg/m³
Additional information

It is considered appropriate to use this result in support of the developmental toxicity endpoint for chlorodimethylsilane as this substance is hydrolysed very rapidly in the presence of moisture to dimethylsilanol and hydrogen chloride. The tested substance, trimethylsilanol is closely related to dimethylsilanol (replacement of -H with -CH3) and both substances have similar physicochemical properties (high water solubility and low log Kow), therefore the toxicological properties are expected to be similar.

Justification for classification or non-classification

There are no data to suggest that chlorodimethylsilane should be classified for adverse effects on reproduction and development.