4,4'-methylenebis[N,N-bis(2,3-epoxypropyl)aniline]

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1985

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: no GLP, no guidelined followed

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Materials and methods

Type of study / information:

Monitoring report on Workplace exposure

Endpoint addressed:

not applicable

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Samples of air were absorbed to Tenax-GC absorption vials, Desorption with acetonitrile and analysis by GC.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

4,4'-Methylenedianiline, oligomeric reaction products with 1-chloro-2,3-epoxypropane

EC Number:

500-062-3

EC Name:

4,4'-Methylenedianiline, oligomeric reaction products with 1-chloro-2,3-epoxypropane

Cas Number:

28390-91-2

IUPAC Name:

4-[(4-aminophenyl)methyl]aniline; 2-(chloromethyl)oxirane

Details on test material:

not specified

Method

Ethical approval:

not applicable

Details on study design:

The Exposure scenario was developed as follows: Adsorptiion vials were placed 10 cm above the liquid resins containing TGMDA either in glass vesels or on plates impregnated with TGMDA in the laboratory, or in 2-4 litre-chamber s containing prepregs heated to 170°C.
Sampling was always between 5 - 15 minutes depending on the exposure.

Exposure assessment:

measured

Details on exposure:

Several scenarios were evaluated:
Heating in a beaker (130°C), heating under addition of hardener to 130°C, mixing at 130°C, dispersion on glassfibrescreen at 70°C, pressing at 170°C, Hardening at 200 °C in a press.

Results and discussion

Results:

The results of samples taken at a distance of 10 cm were between 0.01 - 0.07 mg/m3 air.
Based on these results it was calculated that MY720 in the laboratory air (Lab: 5 x 7 x 3 m = 105 m3) was below 0.23 mg/m3 airr , and the highest value calculated was 0.07 mg/m3., independent of the heating used.

Any other information on results incl. tables

Individual measurements (all at a distance of 10 cmmeasured):

Heating of MY720 to 50°C in a heating unit:       0.01 mg/m3

Heating of MY720 to 130°C in a beaker:        0.01 mg/m3

Addition of hardener HT-976 to MY 720 (130°C):<0.01 mg/m3

mixing at 130°C:                                                  0.03 mg/m3

Dispersion on fibre glass tissue at 70°C:               0.07 mg/m3

Pressing at 170°C in a box                                   0.01 - 0.02 mg/m3

Hardening in a press at 200°C:                            0.02 mg/m3

Applicant's summary and conclusion

Conclusions:

Tested under laboratory conditions, the air concentration of MY720 never exceeded 0.003 ppm or 0.07 mg/m3 air even at heating to 200°C

Executive summary:

The results of samples taken at a distance of 10 cm were between 0.01 - 0.07 mg/m3 air. Based on these results it was calculated that MY720 in the laboratory air (Lab: 5 x 7 x 3 m = 105 m3) was below 0.23 mg/m3 air , and the highest value calculated was 0.07 mg/m3., independent of the heating used.