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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature

Data source

Reference
Reference Type:
publication
Title:
The results of skin testing with food additives and the effect of an elimination diet in chronic and recurrent uticaria and recurrent angioedema.
Author:
Malanin and Kalimo
Year:
1989
Bibliographic source:
Clin. Exper. Allergy 19: 539-543 [as cited in SIDS Document for SIAM 25-Propionic acid, 01-07-2007

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
Principles of method if other than guideline:
Pin prick trials
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Method

Type of population:
other: Patients suffering from chronic urticaria
Controls:
non-urticria individual
Route of administration:
dermal

Results and discussion

Results of examinations:
A reproducible positive pin-prick response to a 5% aqueous solution of propionic acid was obtained in 3 of 91 patients suffering from chronic uticaria; patients were presumed to have prior exposure with propionic acid as a food preservative. There was no response observed among 247 normal control (non-uticaria) subjects.

Applicant's summary and conclusion