Registration Dossier
Registration Dossier
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EC number: 205-739-4 | CAS number: 149-44-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1936
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 936
- Report date:
- 1936
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Evaluation of a toxikokinetic study:
Hug, E.: Absorption and disappearance of sodium formaldehyde sulfoxylate from the blood after administration intravenously or by stomach tube,
CRSBAW: Comptes rendus des séances de la Societe de Biologie et de ses filiales (ISSN: 0037-9026), (1936), Vol 121, pp 579 -81 - GLP compliance:
- no
Test material
- Reference substance name:
- Sodium hydroxymethanesulphinate
- EC Number:
- 205-739-4
- EC Name:
- Sodium hydroxymethanesulphinate
- Cas Number:
- 149-44-0
- Molecular formula:
- CH4O3S.Na
- IUPAC Name:
- sodium hydroxymethanesulphinate
- Details on test material:
- not applicable
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- dog
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Control animals:
- no
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- no effects founds
- Executive summary:
Absorption after dermal exposure:
The substance is an organic salt which is highly soluble in water.Additionally, the human epidermis is an excellent barrier for salts, in particular highly water soluble and charged molecules cannot (easily) penetrate such barrier.
Therefore a relevant dermal absorption is not expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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