Registration Dossier
Registration Dossier
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EC number: 243-815-9 | CAS number: 20427-59-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
- Classification according to Directive 67/548/EEC: Harmful (Xn). R22, Harmful if swallowed.
- Classification according to CLP/GHS: Acute Tox. 4, H302: Harmful if swallowed.
- Classification according to Directive 67/548/EEC: Toxic (T). R23, Toxic by inhalation.
- Classification according to CLP/GHS: Acute Tox. 2, H330: Fatal if inhaled.
Acute oral toxicity:
Three high quality GLP-compliant studies conducted in accordance with internationally accepted guidelines are available for acute oral toxicity. The most sensitive LD50 value obtained was 489 mg/kg bw for combined sexes in the rat (James, 1991a). On this basis, it is concluded that the following classification applies to copper dihydroxide on the basis of acute oral toxicity:
This conclusion is supported by the results obtained in the remaining studies.
Acute inhalation toxicity:
Two high quality GLP-compliant studies conducted in accordance with internationally accepted guidelines are available for acute inhalation toxicity. The most sensitive LC50 value obtained in the rat following a 4 hour exposure was 0.451 mg/l air (Chevalier, 2006). On this basis, it is concluded that the following classification applies to copper dihydroxide on the basis of acute inhalation toxicity:
This conclusion is supported by the result obtained in the remaining high quality study.
Acute dermal toxicity:
Three high quality GLP-compliant studies conducted in accordance with internationally accepted guidelines are available for acute dermal toxicity. In each case the LD50 value obtained in both sexes was > 2000 mg/kg bw. On this basis is is concluded that copper dihydroxide is not classified on the basis of dermal toxicity.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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