Registration Dossier
Registration Dossier
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EC number: 201-251-0 | CAS number: 80-10-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No studies are available. Hydrolysis occurs very rapidly, and systemic exposure is expected to the silanol-containing hydrolysis product. Based on molecular structure, molecular weight, water solibility, and octanol-water partition coefficient it can be expected that the hydrolysis product is likely to be absorbed via the oral, dermal, and inhalation routes. Based on the water solubility, the hydrolysis product is likely to be distributed in the body, and excretion via the renal pathway can be expected. Bioaccumulation is not expected.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
There are no studies available in which the toxicokinetic properties of dichloro(diphenyl)silane have been investigated. Therefore, the toxicokinetic behaviour assessment of the substance and its hydrolysis product was assessed by its physico-chemical properties, the available toxicology studies on the substance itself and structurally related substances. Hydrolysis occurs very rapidly, and systemic exposure is expected to the silicon-containing hydrolysis product. Based on molecular structure, molecular weight, water solubility, and octanol-water partition coefficient it can be expected that the hydrolysis product is likely to be absorbed via the oral, dermal, and inhalation routes. Based on the water solubility, the hydrolysis product is likely to be distributed in the body, and excretion via the renal pathway can be expected. Bioaccumulation is not expected.
The detailed toxicokinetic behaviour assessment of the substance and its hydrolysis product is attached to this section.
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