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In a study performed to a similar procedure to OECD Guideline 305 (Bioconcentration: Flow-through Fish Test), Atlantic cod were exposed to 4-hepthylphenol at a concentration of 15.5 nmol/L (as 4-[14C]heptylphenol) under flow-through conditions with a 192 hour exposure period and a 192 hour elimination period.

The steady state BCF was 555 and the kinetic BCF was 578. Rate constants for uptake and elimination were 29.94 and 0.052/h respectively. 

Elimination of 4-heptylphenol occurred rapidly following first order kinetics with an estimated biological half life of 13 hours. Substantial radioactivity was detected in seawater during the initial part of the elimination period but no radioactivity was detected in water after more than 96 hr recovery in clean seawater.

No radioactivity was detected in tissues of cod at the end of the elimination period, indicating a lack of retention in specific tissues. Radioactivity in autoradiograms extracted with nonpolar and polar solvents was not observed, giving additional support to the conclusion that 4-heptylphenol and metabolites do not bind to specific macromolecules or tissue structures in cod.

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