Registration Dossier

Administrative data

Description of key information

Application of 0.5 ml undiluted substance on shaved intact or abraded rabbit skin areas, coverage not mentioned, and reading up to 72 hours post application yielded mean irritation score 8 of max 8. Reversibility is not reported. Using semi-occlusive dressing for 4 hours, the visible tissue damage caused by m-cresol was indicative of corrosive effects (no scores given, Vernot 1977).
Application of 0.5 ml into the eye of rabbits and observation up to 72 hours post application resulted in mean irritation score 87.3 of max 110 accounting for severe irritancy. Reversibility is not reported (Ind Bio-test Lab Inc 1969).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

IRRITATION TO SKIN

Application of 0.5 ml undiluted substance on shaved intact or abraded rabbit skin areas, coverage not mentioned, and reading up to 72 hours post application yielded mean irritation score 8 of max 8. Reversibility is not reported. Using semi-occlusive dressing for 4 hours, the visible tissue damage caused by m-cresol was indicative of corrosive effects (no scores given, Vernot 1977).

IRRITATION TO EYE

Application of 0.5 ml into the eye of rabbits and observation up to 72 hours post application resulted in mean irritation score 87.3 of max 110 accounting for severe irritancy. Reversibility is not reported (Ind Bio-test Lab Inc 1969).

OVERALL

Based on the results in these studies m-cresol is evaluated as corrosive


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: highly irritating

Justification for classification or non-classification

Overall, based on the results on skin and eye irritation m-cresol is evaluated as corrosive.

Under R67/548/EEC (19. ATP) m-cresol and p-cresol as well as o-cresol are classified as corrosive: R34 = causes burns

According to Regulation (EC) No 1272/2008 the substance is allocated to category 1B of skin corrosive substances, Hazard Communication H314