Registration Dossier
Registration Dossier
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EC number: 203-577-9 | CAS number: 108-39-4
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: in vitro investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- Permeability of human epidermis to the phenolic compounds
- Author:
- Roberts MS, Anderson RA, Swarbrick J
- Year:
- 1 977
- Bibliographic source:
- J Pharm Pharmac 29: 677-683
Materials and methods
- Principles of method if other than guideline:
- Epidermal membranes from human abdominal skin (2.5 cm²) were supported in a glass cell and the amount of m-cresol passsing to the receptor vessel was measured spectrophotometrically at room temperature. The test was conducted twice.
- GLP compliance:
- no
Test material
- Reference substance name:
- m-cresol
- EC Number:
- 203-577-9
- EC Name:
- m-cresol
- Cas Number:
- 108-39-4
- Molecular formula:
- C7H8O
- IUPAC Name:
- m-cresol
- Details on test material:
- m-cresol: not further specified
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: human epidermis in vitro
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- in vitro study
Administration / exposure
- Type of coverage:
- other: in vitro study
- Vehicle:
- water
- Duration of exposure:
- up to 250 minutes
- No. of animals per group:
- in vitro study
Results and discussion
Any other information on results incl. tables
The permaeability coefficient of m-cresol ws 2.54 x 10(exp)-4 cm/min and the lag time for a 0.4 %w/v solution was 15 min.
The threshold concentration for damage i.e. the aqueous concentration at which the permeability coefficient began to increase waa 1.0 %w/v.
Applicant's summary and conclusion
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