Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
All cresol isomers are absorbed across the respiratory and gastrointestinal tract and through the intact skin. (Morinaga 2004, WHO 1995). Cresols are widely distributed throughout the body after uptake. Cresols are mainly conjugated with glucuronic acid and inorganic sulfate and excreted as conjugates with the urine. Minor pathways for m- cresol include hydroxylation of the benzene ring. In addition to urinary excretion, cresols are excreted in the bile, but most part undergo enterohepatic circulation. (WHO 1995).

Key value for chemical safety assessment

Additional information

All cresol isomers are absorbed across the respiratory and gastrointestinal tract and through the intact skin. (Morinaga 2004, WHO 1995). Limited data indicate that cresols are widely distributed throughout the body after uptake. Cresols are mainly conjugated with glucuronic acid and inorganic sulfate and excreted as conjugates with the urine. Minor pathways for m- cresol include hydroxylation of the benzene ring. In addition to urinary excretion, cresols are excreted in the bile, but most part undergo enterohepatic circulation. (WHO 1995).