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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case report
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: case report

Data source

Reference
Reference Type:
publication
Title:
Concentrated cresol intoxication
Author:
Wu M-L, Tsai W-J, Yang Ch-Ch, Deng J-F
Year:
1998
Bibliographic source:
Vet Human Toxicol 40, 341-343

Materials and methods

Study type:
poisoning incident
Principles of method if other than guideline:
oral ingestion of 50%cresol-soap solution
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
p-cresol
EC Number:
203-398-6
EC Name:
p-cresol
Cas Number:
106-44-5
Molecular formula:
C7H8O
IUPAC Name:
4-Methylphenol
Details on test material:
cresol: isomers not specified

Method

Type of population:
general
Subjects:
- Number of subjects exposed: 1
- Sex: male
- Age: 44
no further data
Route of exposure:
oral
Reason of exposure:
other: no information given
Details on exposure:
see section "remarks on results"
Examinations:
see section "remarks on results"
Medical treatment:
see section" remarks on results"

Results and discussion

Clinical signs:
see section "remarks on results"
Results of examinations:
see section "remarks on results"
Effectivity of medical treatment:
see section "remarks on results"
Outcome of incidence:
see section "remarks on results"

Any other information on results incl. tables

A 44 -y old man was found unconcious after ingestion of 300 ml 50% cresol soap solution.

Endotracheal intubation, gastric lavage and activated charcoal were given immediately which reversed his consious. He had dermal burns, esophageal and gastric erosions, pneumoniam mixed metabolic acidosis and respiratory alkalosis, renal and liver function impairment, leucocytosis, and darke urine. acute renal failure and hemolysis developed, but he recovered after hemodialysis and intensive supportive care.

Urine levels of p-cresol, m-cresol, o-cresol and phenol wererespectively 2083, 2059, 125 and 68 mg/g creatinine at 7 hours post-ingestion. Though the amount cresol claimed ingested by the patient (150 g) far exceeded the reported lethal dose (30 -40 g), and multiple complications developed after massive ingestion, this patient recovered.

The renal pulmonary, and hematological effects in this patient might have resulted from the direct toxicity of cresol and its metabolites.

Applicant's summary and conclusion