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Ecotoxicological information

Toxicity to terrestrial plants

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The toxicity of m-cresol to lettuce seedlings (Lactuca sativa) was determined according to OECD Guideline 208 in soil. The EC50 was 69 mg/kg soil d.w. after 7 d, 96 mg/kg soil d.w. after 14 d and 50 mg/L solution after 21 d of incubation. 
The effect concentration was normalised to an OC content of 3.4% , resulting in a corrected EC50 of 233 mg/kg.
However, in case of only one test result is available, the risk assessment should be performed both on this test result and on the basis of the outcome of the aquatic toxicity data. Therefore the equilibrium partitioning method with the PNEC for aquatic organisms is also taken into account for assessment.

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Additional information

Several studies of toxicity of m-cresol towards terrestrial plants were found in the literature.

The scope of the terrestrial effects assessment under the adopted REACH regulation is restricted to soil organisms in a narrow sense and does not actually include adverse effects on soil functions that are only indirectly linked to the biota in soils.

Some tests were designed assessing the influence of m-cresol on germination and growth on moist filter paper or agar treated with the substance. As no soil was used in the tests standardisation of soil effect data to given soil parameters is not possible. Further, converting the results to an appropriate dimension is not applicable. Therefore the results should not be used for the hazard assessment.

Using soil, short-term toxicity of m-cresol to lettuce (Lactuca sativa) was examined. The test compound was incorporated into soil according to OECD-guideline 208. The organic matter of 2 soil types used was given as 1.4 to 1.8 %. Lettuce seed was sown and the weight of the crops (above-ground biomass) was measured after 7 and 14 days. After an exposure period of 14 days, a nominal EC50 of 96 mg/kg soil (dry weight) was obtained. According to TGD (EU 2003), the effect concentration (EC50 96 mg/kg) is corrected for a standard soil with a content of organic matter of 3.4 % resulting in a corrected EC50 of 233 mg/kg. The authors stated that β€œat the end of the test, the concentrations of most phenols in soil had dropped to a low value (< 20% of the initial analysed concentrations)".