m-cresol

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

according to guideline

Guideline:

EPA OPP 72-2 (Aquatic Invertebrate Acute Toxicity Test)

Deviations:

not specified

Principles of method if other than guideline:

Method: other: US EPA, Methods for acute toxicity test with fish, macroinvertebrates, and amphibians. Nat. Environm. Res. Center, Corvallis (1974)

GLP compliance:

no

Analytical monitoring:

yes

Details on sampling:

daily

Test organisms (species):

Daphnia pulicaria

Test type:

flow-through

Water media type:

freshwater

Limit test:

no

Hardness:

707.3 mg/l CaCO3/l

Test temperature:

14 +/- 1°C

pH:

8.1

Dissolved oxygen:

6.5 mg/l (84.5% saturation)

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

> 99.5 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mortality

Validity criteria fulfilled:

not specified

Conclusions:

The acute toxicity of m-cresol to Daphnia pulicaria was determined in a flow-through immobilisation test after an exposure period of 48 h. Based on measured concentrations a 48h-EC50 > 99.5 mg/l was determined.

Executive summary:

The acute toxicity of m-cresol to Daphnia pulicaria was determined in an experiment under fow-through conditions (DeGraeve, 1980). After an exposure period of 48 h the LC50 was reported to be > 99.5 mg/l. The result relates to measured concentration as analytical control was performed.

Reference 2

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Principles of method if other than guideline:

fertilized eggs exposed to test material

GLP compliance:

no

Analytical monitoring:

yes

Details on sampling:

daily

Vehicle:

no

Test organisms (species):

other: Strongylocentrotus droebachiensis (sea urchin)

Details on test organisms:

fertilized eggs

Test type:

static

Water media type:

saltwater

Limit test:

no

Total exposure duration:

96 h

Post exposure observation period:

no

Test temperature:

5 °C

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

ca. 30 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

other: development

Remarks on result:

other: sea urchin

NOEC 3 mg/L was next (lower) concentration tested

Executive summary:

The toxicity of m-cresol to the freshly fertilized eggs of the marine sea urchin Strongylocentrotus droebachiensis was determined by a static test. The EC50 (96 h) is 30 mg/L.

Description of key information

The acute toxicity of m-cresol to Daphnia pulicaria was determined in a flow-through immobilisation test after an exposure period of 48 h. Based on measured concentrations a 48h-EC50 > 99.5 mg/l was determined.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Dose descriptor:

LC50

Effect concentration:

99.5 mg/L

Additional information

Short term toxicity of m-cresol towards various species of aquatic invertebrates was assessed in several experiments.

The acute toxicity of m-cresol to Daphnia pulicaria was determined in an experiment under flow-through conditions. After an exposure period of 48 h the LC50 was reported to be > 99.5 mg/l. The result relates to measured concentration as analytical control was performed.

Another aquatic invertebrate was tested for toxicity. Freshly fertilized eggs of the marine sea urchin Strongylocentrotus droebachiensis were exposed to m-cresol in a static test. The EC50 (96 h) was 30 mg/L.

For risk assessment purposes, only the most reliable study is considered. The study conducted with Daphnia pulicaria was chosen for assessment, as it is the preferred species and the experiments was carried out according to a guideline study, following the state-of-the-art.