m-cresol

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Principles of method if other than guideline:

accumulation of 14C

GLP compliance:

no

Radiolabelling:

yes

Vehicle:

no

Test organisms (species):

Leuciscus idus melanotus

Route of exposure:

aqueous

Test type:

static

Water / sediment media type:

natural water: freshwater

Total exposure / uptake duration:

3 d

Hardness:

100 mg CaO/l

Test temperature:

20-25 °C

pH:

7

Details on test conditions:

5 fish (2-4 g) exposed in closed system

Nominal and measured concentrations:

0.05 mg/l

Reference substance (positive control):

yes

Remarks:

Hexachlorobenzene and several others

Details on estimation of bioconcentration:

concentrations were determined by following radioactivity in fish and water

Type:

BCF

Value:

>= 17 - <= 20

Basis:

whole body w.w.

Calculation basis:

other: after 3 d

Remarks on result:

other: Conc.in environment / dose:0.05 mg/L

Determination of radioactivity includes possible metabolized 
and/or incorporated intermediates

Validity criteria fulfilled:

not specified

Executive summary:

Bioconcentration factors (BCF) in fish (Leuciscus idus melanotus) were determined with 14C-labelled m-cresol. The fish were exposed to a 0.05 mg/l solution of the tests compound. After the test period of 3 days radioactivity was measured in water medium and fish. BCF values of 20 were obtained.

Description of key information

The experimental determined bioconcentration factor (BCF) of m-cresol in fish (Leuciscus idus melanotus) is 20.

Key value for chemical safety assessment

BCF (aquatic species):

20 dimensionless

Additional information

The bioconcentration factor (BCF) in fish (Leuciscus idus melanotus) was determined with 14C-labelled m-cresol. The fish were exposed to a 0.05 mg/l solution of the tests compound. After the test period of 3 days radioactivity was measured in water medium and fish. A BCF value of 20 were obtained.