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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
1965-1972
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study was not performed according to guideline or under GLP. Limited reporting. IP route.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1973

Materials and methods

GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
mouse
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
5.1-5.9 mmmol/kg
No. of animals per sex per dose:
approximately 10
Control animals:
no

Results and discussion

Applicant's summary and conclusion

Executive summary:

In toxic doses administered IP sodium cyanate and thiocyanate produce similar syndromes in mice: tremor, hyper-reactivity and tonic-clonic convulsions. A common pattern of interactions with central nervous system drugs suggests that these anions have similar mechanisms of action. Thiocyanate had highly unpredictable lethal effects. The range of doses which included some deaths and some survivors in each group (at least 10 mice) was 5.1 to 7.9 mmol/kg.