Registration Dossier

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was performed pre-GLP and pre-guideline. Nevertheless it gives a good indication of dermal absorption for this substance.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1970

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
see materials and methods
GLP compliance:
no
Remarks:
pre-GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Potassium thiocyanate, no further information.
Radiolabelling:
yes
Remarks:
14C

Test animals

Species:
human

Administration / exposure

Type of coverage:
open
Vehicle:
acetone
Duration of exposure:
24 hours
Doses:
4 µg/cm2 on a 13 cm2 area
No. of animals per group:
6
Control animals:
no

Results and discussion

Percutaneous absorption
Dose:
4 µg/cm2
Parameter:
percentage
Absorption:
10.15 %
Remarks on result:
other: 24 h
Remarks:
SD 6.60%

Any other information on results incl. tables

See attached table.

Applicant's summary and conclusion

Executive summary:

The authors studied the percutaneous penetration of 21 organic chemicals. The experimental method consisted of the application of the radiolabelled chemical to the human forearm in 6 individuals and quantitating its penetration through the skin by its appearance in urine. The recovery from after urine was 10.15% ± 6.60% of the administered dose for potassium thiocyanate, 4 µg/cm2 on a 13 cm2 area, after a collection period of 120 hours.