Registration Dossier

Identification

Chemical structure
Display Name:
Subtilisin
EC Number:
232-752-2
EC Name:
Subtilisin
CAS Number:
9014-01-1
Molecular formula:
Not available.

Type of substance

Composition:
UVCB
Origin:
other: Enzyme

Other names

Trade names:
Alkaline Protease

Total tonnage band

Total range:
1 000 - 10 000 tonnes per annum

REACH

Registered as:
FULL
Submitted:
Joint Submission

Publication dates

First published:
16-Mar-2011
Last modified:
24-Jul-2019

Chemical safety assessment

Performed for this substance:
YES

Compositions open all close all

Type:
legal entity composition of the substance


Constituent 1
Chemical structure
Reference substance name:
Subtilisin
EC Number:
232-752-2
EC Name:
Subtilisin
CAS Number:
9014-01-1
Molecular formula:
Not available.
Constituent 2
Reference substance name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process
IUPAC Name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 3
Reference substance name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
IUPAC Name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
Reference substance name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
IUPAC Name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
Reference substance name:
Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
IUPAC Name:
Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
Type:
legal entity composition of the substance
State Form:
solid: bulk


Constituent 1
Reference substance name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
IUPAC Name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
Constituent 2
Reference substance name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process
IUPAC Name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 3
Reference substance name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available.
IUPAC Name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
Reference substance name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available. See remarks.
IUPAC Name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
Reference substance name:
Other protein by nitrogen with Kjeldahl method
IUPAC Name:
Other protein by nitrogen with Kjeldahl method
Constituent 6
Reference substance name:
inorganic salts by sulphated Ash
IUPAC Name:
inorganic salts by sulphated Ash
Type:
legal entity composition of the substance
State Form:
solid: bulk


Constituent 1
Reference substance name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class no. 3.4.21.62)
IUPAC Name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class no. 3.4.21.62)
Constituent 2
Reference substance name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available. See remarks.
IUPAC Name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 3
Reference substance name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available. See remarks.
IUPAC Name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
Reference substance name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available. See remarks.
IUPAC Name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
Reference substance name:
Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available. See remarks.
IUPAC Name:
Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
Type:
legal entity composition of the substance
State Form:
liquid


Constituent 1
Reference substance name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class no. 3.4.21.62)
IUPAC Name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class no. 3.4.21.62)
Constituent 2
Reference substance name:
unknown protein, petides
IUPAC Name:
unknown protein, petides
Constituent 3
Reference substance name:
impurities based on carbonhydrates
IUPAC Name:
impurities based on carbonhydrates
Constituent 4
Reference substance name:
impurities based on lipides
IUPAC Name:
impurities based on lipides
Constituent 5
Reference substance name:
impurities based on inorganic salts
IUPAC Name:
impurities based on inorganic salts
Type:
legal entity composition of the substance


Constituent 1
Reference substance name:
Total proteins including enzymes
IUPAC Name:
Total proteins including enzymes
Constituent 2
Reference substance name:
Carbohydrates
IUPAC Name:
Carbohydrates
Constituent 3
Reference substance name:
Lipids
IUPAC Name:
Lipids
Constituent 4
Reference substance name:
Inorganic salts
IUPAC Name:
Inorganic salts
Type:
legal entity composition of the substance
State Form:
solid: bulk


Constituent 1
Reference substance name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
IUPAC Name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
Constituent 2
Reference substance name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process.
IUPAC Name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process.
Constituent 3
Reference substance name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available.
IUPAC Name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
Reference substance name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available. See remarks.
IUPAC Name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
Reference substance name:
Other protein by nitrogen with Kjeldahl method
IUPAC Name:
Other protein by nitrogen with Kjeldahl method
Constituent 6
Reference substance name:
inorganic salts by sulphated Ash
IUPAC Name:
inorganic salts by sulphated Ash
Type:
legal entity composition of the substance
State Form:
solid: bulk


Constituent 1
Reference substance name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
Molecular formula:
Not avaiable
IUPAC Name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
Constituent 2
Reference substance name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available
IUPAC Name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 3
Reference substance name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available.
IUPAC Name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
Reference substance name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available.
IUPAC Name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
Reference substance name:
Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available.
IUPAC Name:
Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
Type:
boundary composition of the substance
State Form:
solid: bulk


Constituent 1
Reference substance name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
Molecular formula:
Not avaiable
IUPAC Name:
Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
Constituent 2
Reference substance name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available
IUPAC Name:
Protein as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 3
Reference substance name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available.
IUPAC Name:
Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
Reference substance name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available.
IUPAC Name:
Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
Reference substance name:
Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
Molecular formula:
Not available.
IUPAC Name:
Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
Type:
legal entity composition of the substance
State Form:
solid: bulk


Constituent 1
Chemical structure
Reference substance name:
Subtilisin
EC Number:
232-752-2
EC Name:
Subtilisin
CAS Number:
9014-01-1
Molecular formula:
Not available.
Constituent 2
Reference substance name:
amino acids
IUPAC Name:
amino acids
Constituent 3
Reference substance name:
Carbohydrates
IUPAC Name:
Carbohydrates
Constituent 4
Reference substance name:
Extractable lipids
IUPAC Name:
Extractable lipids
Constituent 5
Chemical structure
Reference substance name:
Dipotassium phosphonate
EC Number:
236-809-2
EC Name:
Dipotassium phosphonate
CAS Number:
13492-26-7
Molecular formula:
H3O3P.2K
IUPAC Name:
Dipotassium phosphonate
Constituent 6
Chemical structure
Reference substance name:
Sodium sulphate
EC Number:
231-820-9
EC Name:
Sodium sulphate
CAS Number:
7757-82-6
Molecular formula:
H2O4S.2Na
IUPAC Name:
Sodium sulphate
Constituent 7
Chemical structure
Reference substance name:
Sodium chloride
EC Number:
231-598-3
EC Name:
Sodium chloride
CAS Number:
7647-14-5
Molecular formula:
ClNa
IUPAC Name:
sodium chloride

Registrants /Suppliers of the substance open all close all

Latest dossier received
Registrant / Supplier details 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019
o BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany X
Beckman Coulter France SAS Paris Nord 2 33 Rue des Vanesses 95942 Roissy CDG CEDE France X
o CHT Germany GmbH Bismarckstr. 102 72072 Tuebingen Germany X
o CYGYC INDUSTRIA QUIMICA, S.A. Pol. Ind. Pla de Llerona - C/ Belgica, 5 08520 Les Franqueses del Vallés Spain X
o Genencor International B.V. - OR-US Archimedesweg 30 2333 CN Leiden Netherlands X
o Genencor International BVBA Komvest 43 8000 Brugge Belgium X
o Genencor International Oy Tiilikantie 15 FI-42300 Jämsänkoski Finland X
o Novozymes A/S Krogshoejvej 36 2880 Bagsvaerd Denmark X
OLON Spa Strada Rivoltana Km 6/7 20090 RODANO Milano Italy X
PHARMEGIC HEALTHCARE LIMITED Unit 23, Trinity Technology and Enterprise campus, Pearse Street D02WR66 Dublin 2 Ireland X
ServiREACH, S.A. Rambla Jaume Sabat, 4 08172 Sant Cugat del Vallès Barcelona Spain X
Sustainability Support Services (Europe) AB Markaskälsvägen 6 22647 Lund Sweden X

Administrative data open all close all

  • 01-2119480434-38-0000
  • 01-2119480434-38-0001
  • 01-2119480434-38-0002
  • 01-2119480434-38-0003
  • 01-2119480434-38-0004
  • 01-2119480434-38-0005
  • 01-2119480434-38-0006
  • 01-2119480434-38-0007
  • 01-2119480434-38-0008
  • 01-2119480434-38-0009
  • 01-2119480434-38-0010
  • 01-2119480434-38-0011

Contact Persons responsible for the SDS