2-(2-(2-butoxyethoxy)ethoxy)ethanol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Original study in German

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Materials and methods

Principles of method if other than guideline:

Estimation of the approximate LD50 value according to BASF-internal standard

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-(2-(2-butoxyethoxy)ethoxy)ethanol

EC Number:

205-592-6

EC Name:

2-(2-(2-butoxyethoxy)ethoxy)ethanol

Cas Number:

143-22-6

Molecular formula:

C10H22O4

IUPAC Name:

2-[2-(2-butoxyethoxy)ethoxy]ethanol

Details on test material:

no data

Test animals

Species:

rat

Strain:

other: US rats

Sex:

male/female

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

Observation period: 14 days
Test substance given as 2, 20 and 30% aqueous solution

Doses:

200, 1600, 3200, 4000, 5000, 6400 mL/kg

No. of animals per sex per dose:

10

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

approximate LD50

Effect level:

ca. 5 170 mg/kg bw

Based on:

test mat.

Remarks on result:

other: value original cited in report as 5.2 mL/kg

Mortality:

see table below

Clinical signs:

other: Dose groups 6400, 5000, 4000, 3200 mL/kg: Staggering, opisthotonos, prone/lateral-position, atony, slight dyspnea shortly after application following aneasthesia. 8/10 animals of the highest dose group died during the induced aneasthesia. In the other gr

Gross pathology:

sometimes bloody urine, several kidney damage

Any other information on results incl. tables

Dose (cmm/kg)	Conc. (%)	No. of animals	Total number of dead animals within
			1 hour	24 hours	48 hours	7 days	14 days
6400	30	10	5/10	9/10	9/10	9/10	9/10
5000	30	10	0/10	5/10	5/10	5/10	5/10
	30	10	1/10	3/10	3/10	3/10	3/10
4000	30	10	0/10	1/10	1/10	1/10	1/10
	30	10	2/10	4/10	5/10	5/10	5/10
3200	30	10	1/10	1/10	2/10	2/10	2/10
1600	20	10	0/10	0/10	0/10	0/10	0/10
200	2	10	0/10	0/10	0/10	0/10	0/10

Applicant's summary and conclusion

Interpretation of results:

not classified

Conclusions:

Based on the effects seen at doses at or below the limit dose of 2000 mg/kg, classification for STOT RE effects is not considered appropriate or necessary

Executive summary:

In a reliable acute oral toxicity study where original data is available, male and female rats were subjected to doses of up to 6400ml/kg of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and subsequently observed for a period of 14 days. An LD50 value of ~5170mg/kg was obtained.