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EC number: 424-110-7 | CAS number: 194602-23-8 UK-143,108
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 3 and 7 February 1997.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under GLP and OECD method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Method C1, Directive 92/69/EEC
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Principles of method if other than guideline:
- The study was conducted in accordance with EEC Methods for Determination of Ecotoxicity Annex to Directive 92/69/EEC (O.J. No. L383A, 29.12.92) Part C, Method 1 "Acute toxicity for Fish" and the OECD Guideline for Testing of Chemicals No. 203 "Fish, Acute Toxicity Test".
- GLP compliance:
- yes
Test material
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Identity: UK-143,108
Chemical name: 2-Ethoxy-5-( 4-methyl-1-piperazinesulphonyl) benzoic acid
Intended use: Pharmaceutical intermediate
Appearance: White to off-white powder
Storage conditions: Room temperature in the dark
Sample reference: CPI/96 070
Expiry date: Not supplied
Purity: 101.3%
Date received: 2 October 1996
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- At the beginning and then at 96hrs for the 22, 48 and 100 % concentrations. Also ran a stability sample concurrent to look for maintenace of test solution concentration.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Identity and concentration of auxiliary solvent for dispersal: No auxiliary solvents were required. Neat
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Rainbow trout
Source: Westacre Trout Farm, Norfolk, UK.
Acclimatisation
The stock of fish was obtained from the supplier on 20 September 1996 and acclimatised to test conditions from 26 December 1996. Temperature remained at I 5°C and dissolved oxygen within the range 9.0 to 9.7 mg02/l in the 14-day period immediately prior to the study. The fish were fed daily to repletion with commercial fry pellet but food was not given during the 24 hour period immediately prior to exposure or during the exposure period itself. No medication was given during the acclimatisation period and no mortalities were recorded in the 7 days prior to the test.
Control fish were measured at the end of the exposure period. The mean standard length was 5.97 cm (SD = 0.407) and the mean weight was 3.06 g (SD = 0.581).
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- Observations were made on the numbers of dead fish and the incidence of sub-lethal effects after 3, 6, 24, 48, 72 and 96 hours exposure
Test conditions
- Test temperature:
- Treatment and control groups were maintained at 13 ± 1°C throughout the exposure period
- pH:
- Between 7.78 and 7.94
- Dissolved oxygen:
- 9.80mgO/I
- Nominal and measured concentrations:
- Nominal concentrations:4.6, 10, 22, 46 and 100 mg/I
Mean measured concentrations: 4.77, 10.2, 22.5, 47.1, and 101 mg/I - Details on test conditions:
- Following preliminary range finding between 0.1 and 100 mg/I, 5 test concentrations were chosen plus one untreated control. Seven fish were added to each vessel.
Fish were placed at random in glass aquaria containing prepared test medium or diluent water. Each vessel contained 40 litres of medium to a depth of 27 cm (approximate dimensions of vessel: 32 x 53 x 38 cm). This provided a loading of 0.536 g bodyweight/litre. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- A single dead fish was observed in the 46 mg/I test concentration after 48 hours of this study. This level of mortality, along with the absence of sublethal effects, is not considered to be biologically significant and therefore the no observed effect concentration (NOEC) is 100 mg/I.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96 h LC50 value for UK-143,108 with rainbow trout was >100 mg/I.
The 'no-observed effect concentration' for UK-143,108 with rainbow trout is considered to be 100 mg/I, the highest concentration tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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