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EC number: 424-110-7 | CAS number: 194602-23-8 UK-143,108
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 November and 9 December 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to an OECD Method and in accordance with GLP. The study material is well characterized.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Principles of method if other than guideline:
The soil adsorption coefficient was determined by the high performance liquid chromatography (HPLC) method as described in OECD draft document TGP/94.75 (April 1994).- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Intended use: Pharmaceutical intermediate
Appearance: White powder
Storage conditions: Room temperature
Expiry date: Not supplied
Purity: 99.4%
Date received: 2 October 1996
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- No data
HPLC method
- Details on study design: HPLC method:
- The soil adsorption coefficient is defined as the ratio between the concentration of the test substance in the soil and the concentration of the test substance in the aqueous phase, both measured when the adsorption equilibrium is reached
Column: Cyano Spherisorb, 25 cm x 4.6 mm id, 5 µm particle size.
Mobile phase: 55 : 45 v/v potassium dihydrogen citrate buffer (O.OlM) at pH 6: methanol.
Flow rate: 1.0 ml/min.
Pressure: 2500 psi.
Analytical wavelength: 245 nm.
Injection volume: 10 µI.
Range: -10 to 500 mV.
Batch equilibrium or other method
- Analytical monitoring:
- yes
- Details on sampling:
- Autosampler: Model 712 WISP, Waters Associates
- Details on matrix:
- No Data
- Details on test conditions:
- PREPARATION OF TEST SOLUTION
Test substance (0.10971 g) was weighed into a volumetric flask (100 ml) dissolved in and made to volume with methanol.
An aliquot (15 ml) of this solution was diluted to 100 ml with mobile phase.
The quantity oftest substance introduced onto the HPLC column in a 10 µl injection was 1645.7 ng.
- Computational methods:
- No Data
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- Koc
- Value:
- < 60.3
- Remarks on result:
- other: PH 7
- Type:
- log Koc
- Value:
- < 1.78
- Remarks on result:
- other: PH 7
Results: HPLC method
- Details on results (HPLC method):
- Calibration data for the reference compounds are given in Table 6. The dead time (t0) was determined as 3.109 minutes (mean of3.110 and 3.107 minutes). The mean retention times of the reference compounds were Monolinuron 5.762 minutes and Isoproturon 6.365 minutes. A mean retention time of 3.280 minutes was obtained, indicating that the test substance was hardly retained. The retention time ofUK-143,108 is less than the lowest available standard (Monolinuron) and is therefore considered to have a soil adsorption coefficient less than that of Monolinuron ie Koc value less than 60.3, log Koc value less than 1.78.
Results: Batch equilibrium or other method
- Adsorption and desorption constants:
- No Data
- Recovery of test material:
- No Data
- Concentration of test substance at end of adsorption equilibration period:
- No Data
- Concentration of test substance at end of desorption equilibration period:
- No Data
- Details on results (Batch equilibrium method):
- No Data
- Statistics:
- No Data
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The soil adsorption coefficient for UK-143,108 has been determined as:
Log Koc< 1.78 at pH 7
Koc < 60.3 at pH 7
The result indicates that the test substance is likely to be moderately or highly mobile in soil.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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