Registration Dossier
Registration Dossier
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EC number: 306-479-5 | CAS number: 97280-83-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliability-grading was adopted from the OECD SIDS higher olefins (IUCLID data set 1-Hexadecene)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Higher Olefins-Category
- Author:
- OECD SIDS
- Year:
- 2 004
- Bibliographic source:
- SIDS Initial Assessment Report For SIAM 19
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- not specified
- Remarks:
- GLP according to SIDS record
- Type of study:
- Buehler test
Test material
- Reference substance name:
- 1-hexadecene
- IUPAC Name:
- 1-hexadecene
- Reference substance name:
- 629-73-1
- IUPAC Name:
- 629-73-1
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 330 to 526 grams
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: acetone
- Concentration / amount:
- Induction: presumably 10% (0.5 ml)
Challenge: presumably 2.5%
Challenge
- Concentration / amount:
- Induction: presumably 10% (0.5 ml)
Challenge: presumably 2.5%
- No. of animals per dose:
- Rangefinding Group: 4 males and 4 females
Test Group: 10 males and 10 females
Naive Control Group: 5 males and 5 females - Details on study design:
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 3
- Exposure period: 6 hours
- Frequency of applications: 1/week
- Concentrations: presumably 10%
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Evaluation (hr after challenge): 24 and 48
- Concentrations: presumably 2.5 %
see also: Any other information
Results and discussion
Any other information on results incl. tables
All animals were +/--
Number of animals with skin reaction at challenge: 0/10
Number of animals with skin reaction in control group at challenge: 0/10.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
