Registration Dossier
Registration Dossier
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EC number: 202-180-8 | CAS number: 92-70-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract information in OECD SIDS report of 2004; study described in OECD SIDS as valid without restrictions.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 19 - 3-Hydroxy-2-naphthoic acid
- Author:
- Anonymous
- Year:
- 2 004
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-hydroxy-2-naphthoic acid
- EC Number:
- 202-180-8
- EC Name:
- 3-hydroxy-2-naphthoic acid
- Cas Number:
- 92-70-6
- Molecular formula:
- C11H8O3
- IUPAC Name:
- 3-hydroxy-2-naphthoic acid
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- semiocclusive
- Duration of treatment / exposure:
- 4h
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: no data
- Score:
- 0.3
- Reversibility:
- fully reversible within: 48h
- Remarks on result:
- other: scores for both edema and erythema
Applicant's summary and conclusion
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