3-methylbutan-1-ol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-finding toxicity data: List VII

Author:

Smyth HF et al.

Year:

1969

Bibliographic source:

Am. Ind. Hyg. J. 30, 470-476

Reference 2

Reference Type:

secondary source

Title:

Fragrance raw materials monographs - Isoamly alcohol

Author:

Opdyke DLJ

Year:

1978

Bibliographic source:

Food Chem. Tox. 16, S1, 785-788

Reference 3

Reference Type:

secondary source

Title:

No information

Author:

RIFM

Year:

2009

Bibliographic source:

RIFM database

Materials and methods

Principles of method if other than guideline:

acc. to Smyth HF et al., Am. Ind. Hyg. Assoc. J. 23, 95, 1962

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-methylbutan-1-ol

EC Number:

204-633-5

EC Name:

3-methylbutan-1-ol

Cas Number:

123-51-3

Molecular formula:

C5H12O

IUPAC Name:

3-methylbutan-1-ol

Test animals

Species:

rabbit

Strain:

other: albino

Test system

Type of coverage:

open

Preparation of test site:

other: clipped

Vehicle:

other: undiluted or as a solution in water, propylene glycol or acetone

Controls:

not specified

Amount / concentration applied:

0.01 ml

Duration of treatment / exposure:

24 h

Observation period:

24 h

Number of animals:

5

Details on study design:

TEST SITE
- Area of exposure: uncovered belly

SCORING SYSTEM:
Irritation grades that ranged from 1 to 10:
grade 1 = no irritation;
2 = least visible capillary injection from the undiluted material;
6 = higher necrosis with the undiluted material;
10 = necrosis from a 0.01% solution

Results and discussion

In vivo

Results

Irritation parameter:

other: Irritation score

Basis:

other: not further specified

Time point:

other: 24 h

Score:

2

Max. score:

10

Reversibility:

no data

Any other information on results incl. tables

Irritation on uncovered rabbit belly was reported to be of grade 2 of 10,  where Grade 1 indicates no irritation and grade 2 the least visible  capillary injection from 10 µl of the undiluted chemical.