Registration Dossier
Registration Dossier
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EC number: 204-633-5 | CAS number: 123-51-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Narcotic and Toxic Potency of Aliphatic Alcohols upon Rabbits
- Author:
- Munch JC and Schwartze EW
- Year:
- 1 925
- Bibliographic source:
- J. Lab. Clin. Med., 10:985
- Reference Type:
- secondary source
- Title:
- Narcotic and toxic potency of aliphatic alcohols upon rabbits
- Author:
- Munch JC and Schwartze EW
- Year:
- 1 972
- Bibliographic source:
- Ind. Med. 41, 31-33
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- RIFM
- Year:
- 2 009
- Bibliographic source:
- RIFM database
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- NIOSH
- Year:
- 2 008
- Bibliographic source:
- RTECS
Materials and methods
- Principles of method if other than guideline:
- acute oral toxicity study
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- - Name of test material (as cited in study report): Isoamylalcohol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: from regular dealers
- Weight at study initiation: 1.5 - 2.5 kg
- Fasting period before study: alfalfa hay and oats ad libitum, and carrots were offered several times a week.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- physiological saline
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 5 ml - Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 24 h
- Frequency of observations and weighing: continual observation
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 438 mg/kg bw
- Remarks on result:
- other: calculated
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 39 other: mmol/kg bw
Any other information on results incl. tables
Narcotic Dose (ND50) of 8 mmol/kg bw was determined as that quantity producing stupor, loss of voluntary movements in half of the rabbits.
Applicant's summary and conclusion
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