3-methylbutan-1-ol

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Uptake of 10 polar organic solvents during short-term respiration

Author:

Kumagai S, Oda H, Matsunaga I, Kosaka H and Akasaka S

Year:

1999

Bibliographic source:

Toxicological Sciences (formerly Fundamental & Applied Toxicology), 48(2), 255-263

Reference 2

Reference Type:

secondary source

Title:

No information

Author:

RIFM

Year:

2009

Bibliographic source:

RIFM database

Materials and methods

Objective of study:

excretion

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-methylbutan-1-ol

EC Number:

204-633-5

EC Name:

3-methylbutan-1-ol

Cas Number:

123-51-3

Molecular formula:

C5H12O

IUPAC Name:

3-methylbutan-1-ol

Details on test material:

- Name of test material (as cited in study report): iso-pentyl alcohol

Radiolabelling:

no

Test animals

Species:

human

Strain:

other: not applicable

Sex:

not specified

Administration / exposure

Route of administration:

inhalation: vapour

Vehicle:

other: air

Details on exposure:

TYPE OF INHALATION EXPOSURE: mouth only


GENERATION OF TEST ATMOSPHERE / CHAMPER DESCRIPTION
- System of generating particulates/aerosols: the subjects breathed through a mouthpiece with one-way valves. The inlet of this mouthpiece was connected to the test air in a 100-L Tedlar bag or room air. The outlet of the mouthpiece was connected to a 10-L Tedlar bag for collection of the mixed exhaled air
- Treatment of exhaust air: To avoid loss of the exhaled solvent vapor in condensed water, the connecting metal tubes, the mouthpiece and the three-way valves were kept at a constant temperature of 40 °C by means of a heating coil.

Duration and frequency of treatment / exposure:

10 minutes

Doses / concentrations

Remarks:

Doses / Concentrations:
25 ppm

No. of animals per sex per dose / concentration:

Four healthy male volunteers

Control animals:

not specified

Details on dosing and sampling:

PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: exhaled air

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:

The mean respiratory rate for isoamyl alcohol was 15.3 min-1, which was slightly higher than the other solvents tested. The mean tidal volume in each solvent was from 470 to 530 ml and no significant difference was found among the solvents tested. The percentage of isoamyl alcohol in the end-exhaled air and in the mixed-exhaled air increased after the start of the test-air respiration, and reached a quasi-steady-state level within a few minutes. The speeds of these increases at the start of the test-air respiration became lower as partition coefficients of blood/air increased. The mean uptakes for the last five minutes of test air respiration were 63.0%.