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Key value for chemical safety assessment

Additional information

In the bacterial gene mutation assay MMEA was not mutagenic with and without metabolic activation (Zeiger, 1987).

In a chromosome-aberration test performed using V79 cells, MMEA did not lead to a relevant increase in the number of structural chromosomal aberrations in the absence and presence of metabolic activation (BASF AG, 2008). The types and frequencies of structural chromosome aberrations were close to the range of the concurrent negative control values at both sampling times and clearly within in the range of the historical negative control data. MMEA did also not induce mutation at the hprt locus of L5178Y mouse lymphoma cells

up to highly toxic concentrations tested (BASF AG, 2010).

N-Methylethanolamine is stated to be nonmutagenic.

Justification for selection of genetic toxicity endpoint
No study is selected since all studies are negative

Short description of key information:
Zeiger etal., 1987. Salmonella Mutagenicity Tests: III.Results From the Testing of 255 Chemicals. Publication
BASF AG, 2008. In vitro mammalian chromosome-aberration test. According to the GLP and OECD guideline 473.
BASF AG, 2010. Mutation at the hprt locus of L5178Y mouse lymphoma cells using the Microtitre R fluctuation technique. According to the GLP and OECD guideline 476.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The classification is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulations No 1272/2008.