Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-870-1 | CAS number: 111-44-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information from assessment report, no study details were provided.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- No information
- Author:
- Agency for Toxic Substances and Disease Registry, U. S. Public Health Services
- Year:
- 1 989
- Bibliographic source:
- http://www.atsdr.cdc.gov/toxprofiles/tp127.pdf
Materials and methods
- Principles of method if other than guideline:
- no information
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Bis(2-chloroethyl) ether
- EC Number:
- 203-870-1
- EC Name:
- Bis(2-chloroethyl) ether
- Cas Number:
- 111-44-4
- Molecular formula:
- C4H8Cl2O
- IUPAC Name:
- 1-chloro-2-(2-chloroethoxy)ethane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 250 ppm
- Exp. duration:
- 4 h
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 1 462 mg/m³ air
- Exp. duration:
- 4 h
- Remarks on result:
- other: mg/m³ calculated as mg/m³ = ppm *(MW/24.45)=ppm*(143.01/24.45)=250*143.01/24.45=1462 mg/m³
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 4 h LD50 inhalation is about 1.46 mg/L (250 ppm)
- Executive summary:
"Exposure of rats to 250 ppm for 4 hours caused death in about half the animals (Carpenter et al. 1949)." (cited in ATSDR 1989, page 14)
This is equivalent to 1.462 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
