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Physical & Chemical properties

Dissociation constant

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Description of key information

pKa = 8.87 (HPLC)
pKa = 8.16 (25°C, potentiometry)
pKa = 8.35 (review article)

Key value for chemical safety assessment

pKa at 20°C:
8.46

Additional information

Several reliable sources reporting consistently similar values for the pKa of Propylparaben in the range of 8.16 to 8.87 determined by different methods. Considering all available values in a weight-of-evidence approach results in an average value of pKa = 8.46 for the dissociation constant of the hydroxylic function of Propylparaben. This value was used as key value for chemical safety assessment.