2-(dimethylamino)ethyl acrylate

Endpoint summary

Description of key information

Based on the key studies for skin and eye irritation the test substance is considered to be corrosive to the skin (BASF AG, 1982) and highly irritating to the eye (BASF AG, 1979). The substance may be (highly) irritating to the respiratory tract.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Additional information

Skin irritation/corrosion:

There are four reports available. Among them, the study by BASF AG (1982) was identified as the key study because it was conducted according to OECD TG 404. In this study, the undiluted test substance was applied to the intact skin of six New-Zealand White rabbits at a dose level of 0.5 ml per animal under semiocclusive and occlusive conditions for 3 minutes, 1 hour or 4 hours. According to the cutaneous reactions 24, 48 and 72 hours after the 4-hours exposure under semiocclusive conditions the test substance is considered to be corrosive to the skin.

The other studies, that were all performed in rabbits, do not provide additional information on the skin irritation/corrosion potential because according to all reports the test substance is considered to be corrosive to the skin (Potokar et al., 1984; BASF AG, 1979; Atochem, 1981).

Eye irritation:

There are two reports available. The study by BASF AG (1979) was identified as the key study because it was conducted according to the recommendations of the Federal Register 38, No. 187, § 1500.41, p. 27019 from 27 Sep. 1973. The irritant/corrosive response data in the eyes of three Vienna White rabbits after application of 0.1 ml undiluted test substance were not fully reversible within 8 days. The test substance is considered to be highly irritating to the eye.

In the second study by Atochem (1981), severe cornea, iris and conjunctivae lesions were displayed in all two rabbits within 1 hour after the instillation of 0.1 ml undiluted substance that was removed by washing 4 seconds after application. Although the test was terminated after 1 hour on humane grounds, it is reasonable to assume that similar levels of injury would be produced if full scale testing were conducted, and that the test substance would be classified as severly irritating or corrosive to the eye.

Respiratory irritation:

There exists no standard test method for the assessment of respiratory irritation. There is some evidence from several inhalation hazard tests that 2-(dimethylamino)ethyl acrylate vapour and aerosol may be irritating to the nose, eyes and respiratory tract of rats (BASF AG 1979, Atochem 1991). Since the substance is classified as corrosive, the potential to cause respiratory tract irritation is implicitly covered.

 

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Effects on respiratory irritation: highly irritating

Justification for classification or non-classification

EU classification according to Annex VI of the Directive 67/548/EEC:

- Skin irritation/corrosion: Causes burns, R34

- Eye irritation: Results from eye irritation studies fulfill the criteria for assignment of the risk phrase "Risk of serious eye damage (R41)". However, since the substance is classified as corrosive and assigned R34, the risk of severe damage to eyes is considered implicit and R41 is not included in the label.

- Respiratory irritation:

Since the substance is classified as corrosive, the potential to cause respiratory tract irritation is implicitly covered.

GHS classification according toAnnex I 1272/2008 CLP (EU GHS):

- Skin irritation/corrosion Cat. 1B

- Respiratory irritation: Since the substance is classified as corrosive, the potential to cause respiratory tract irritation is implicitly covered.