Registration Dossier
Registration Dossier
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EC number: 224-052-0 | CAS number: 4180-23-8
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Lack of influence of modulators of epoxide metabolism on the genotoxicity of trans-anethole in freshly isolated rat hepatocytes assessed with the unscheduled DNA synthesis assay
- Author:
- A.D. Marshall and J. Caldwell
- Year:
- 1 996
- Bibliographic source:
- Food and Chemical Toxicology 34 (1996) 337-345
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 486 (Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo)
- GLP compliance:
- not specified
- Type of assay:
- unscheduled DNA synthesis
Test material
- Reference substance name:
- (E)-anethole
- EC Number:
- 224-052-0
- EC Name:
- (E)-anethole
- Cas Number:
- 4180-23-8
- Molecular formula:
- C10H12O
- IUPAC Name:
- 1-methoxy-4-prop-1-en-1-ylbenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- trioctanonin (1 mL/kg bw)
- Duration of treatment / exposure:
- 5h
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
1E-6 - 1E-2 M
Basis:
analytical conc.
- Remarks:
- Doses / Concentrations:
0, 1, 125, 500 mg/kg
Basis:
nominal conc.
- Control animals:
- yes
- Positive control(s):
- 2-acetylaminofluorene (2-AAF) and methyleugenol
Examinations
- Tissues and cell types examined:
- hepatocytes
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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