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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

N,N-dimethylbenzylamine  is corrosive to the skin and highly irritating to the eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information


N,N-dimethylbenzylamine was applied to the skin of rabbits to evaluate the irritant potency the test was performed according to OECD TG 404 and resulted in severe erythema score 4 of (max) 4 including black areas, crusts, edema, slight to severe indurations. According to these severe skin reactions observed (deep red to black injuries) the animals were kept only for an observation period of 24 hours they were killed due to ethical reason after this period (BG Chemie 1987)


Groups of 5 rabbits received N,N-dimethylbenzylamine into the conjunctival sac of one eye of each rabbit (second eye served as control) and were observed up to 7 days post dosing: (1) 0.005 ml of undiluted test material resulting in severe corneal opacity and iritis and marked chemosis but eyes recovered by 7 days, (2) 0.5 ml of a 5% test material solution in propylene glycol resulting in moderate to severe corneal injury and iritis and chemosis; the eyes of 4/5 rabbits recovered within 10 days. One rabbit exhibited corneal injury, with vascularization, and conjunctival irritation after 10 days. (3) 0.5 ml of a 1% test material solution in propylene glycol which caused no reactions in the eyes during the observation period. Overall, N,N-Dimethylbenzylamine was evaluated as a severe irritant (Ballantyne 1985).

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: highly irritating

Justification for classification or non-classification

According to Regulation (EC) 1272/2008 (CLP/GHS) N,N-Dimethylbenzylamine is already classified and labelled:

for Skin Corrosion Category 1B (H314)

The availble data support this classification and labelling.