Registration Dossier
Registration Dossier
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EC number: 203-299-8 | CAS number: 105-45-3
Endpoint summary
Administrative data
Description of key information
Additional information
Environmental Fate
Methyl acetoacetate (MAA) is a colourless, organic liquid. The substance is a mono-constitutent substance with high purity and a relative density of 1.0767. The physical chemical properties indicate that MAA would be expected to be found in water. The vapor pressure is relatively low (0.187 hPa at 20 °C) indicating that MAA is slightly to moderately volatile. MAA is considered highly soluble. The water solubility for MAA was determined to be > 1000 g/L. Therefore, MAA is expected to be soluble and mobile in the aquatic environment.
Biodegradation in water
MAA was shown to be ready and inherently biodegradable. In the key study, MAA was tested according to OECD Guideline 301 F (Ready biodegradability: Manometric Respiration Test). After 28 days of exposure, the rate of biodegradation amounted to 94%. In a supporting inherent biodegradation study similar to the Zahn-Wellens method according to OECD 302B, an elimination of 100% after 5 days was reached.
Biodegradation in sediment
Sediment simulation testing was not conducted as direct and indirect exposure to sediment is unlikely. The test substance entering the water is not likely to sorb onto suspended solids and sediment based upon the log Pow of -0.4.
Biodegradation in soil
Soil simulation testing does not need to be conducted as there is no direct or indirect exposure to soil for this test substance.
Potential for Bioaccumulation
MAA is not likely to bioaccumulate. Experimental determination of bioaccumulation was waived based on its water solubility, partition coefficient and biodegradability. MAA is readily and inherently biodegradable, the log octanol water partition coefficient was shown to be -0.4 and the water solubility to be > 1000 g/L.
Adsorption/desorption
Testing for adsorption/desorption was waived, as the substance is expected to have a low potential for adsorption (log Pow = -0.4). Further, the substance and its relevant degradation products decompose rapidly (ready and inherently biodegradable). The Koc was estimated to be 6.821 L/kg (log Koc 0.8339) at 25°C for the MCI method.
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