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Administrative data

Description of key information

About Samarium oxide no studies were available, but about the analogue substance Lanthanum carbonate:
Oral:
LD50 (rats) > 30404 mg/kg bw Lanthanum carbonate

Key value for chemical safety assessment

Additional information

Oral

The acute oral toxicity of Lanthanum carbonate monohydrate was tested according to the Guideline of the Department of Transportation (D.O.T), Code of Federal Regulations, Title 49, Part 173 (Ward, 1976). The test substance was administered to rats in a limit test at a dose of 31600 mg/kg bw, mortality and clinical signs were observed for 48 h. Since no mortality occurred and no clinical signs were detected, the LD50 was stated as greater than 30404 mg Lanthanum carbonate/kg bw.

Furthermore, in an acute oral toxicity study according to OECD 423, a first group of 3 females was given a single oral dose of Lanthane carbonate (containing water) as such in PEG 300 at a dose of 2000 mg/kg bw and observed for 14 days (Ott, 2005). As no death and no clinical signs were observed, a second group of 3 females was tested under the same test conditions. No mortality and only minor clinical signs (slightly ruffled fur and hunched posture observed up to 3 days of the study) were observed in the second group of animals. The LD50 was stated as greater than 2000 mg/kg bw (corresponding to 1367 mg Lanthanum carbonate/kg bw).

Justification for classification or non-classification

The data on acute toxicity oral exposure are conclusive but not sufficient for classification according to the criteria of Directives 67/548/EEC (DSD) and 1272/2008/EC (CLP).