Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-743-8 | CAS number: 7299-99-2
Radioactivity Measurements (Individual Animals)
DPM / Animal
Acetone / Olive Oil (4:1 v/v)
5% test substance
50% test substance
100% test substance
Calculation of Stimulation Index (SI)
DPM ± SD
SI ± SD
192 ± 108
326 ± 167
1.7 ± 0.9
471 ± 127
2.4 ± 0.8
195 ± 146
Read across to structural analogue. Structural details are listed above.
The SI values calculated for the substance concentrations 5, 50 and 100% were 1.0, 1.7 and 2.4 respectively.
These data showed a dose-response but there was no indication that the test substance could elicit a SI ≥ 3.
Based on these results and according to the recommendations made in the test guidelines (OECD No.429, EC B.42 and EPA OPPTS 870.2600), HATCOL 3331 should not be regarded as a skin sensitiser
Conclusions for sensitizing properties of 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]propane-1,3-diyl bis(2-ethylhexanoate)(EC# 230-743-8) are based on read across from analogue substances of an existing category (pentaerythritol esters), of which the members were notified under Directive 67/548/EEC (NONS) in 2003/2004. The substance is considered not to be a skin sensitizer.
Results are as follows:
The substance is not considered not to be a respiratory sensitiser on the basis of experience in use and the ester group as a whole. No effects are proposed. No classification is applicable.
Based on the above mentioned result, classification according to the CLP Regulation (EC) 1272/2008 is not necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again