Registration Dossier

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
no hazard identified

Marine water

Hazard assessment conclusion:
no hazard identified

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
10 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
no hazard identified

Sediment (marine water)

Hazard assessment conclusion:
no hazard identified

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
no hazard identified

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusions for2,2-bis[[(2-ethyl-1-oxohexyl) oxy]methyl]propane-1,3-diyl bis(2-ethylhexanoate) (EC# 230-743-8) are based on read across from analogue substances of a known category of which the members were notified under Directive 67/548/EEC (NONS) in 2003/2004.

 

Based on the similar physico-chemical properties obtained for all members of the category in combination with the available experimental data for environmental endpoints, it can be expected that all substances would cause similar environmental toxicity,despite the variation of chain length and the presence of branchedvs. linear fatty acid esters. With an average molecular weight of 640, the substance of interest, i.e. 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]propane-1,3-diyl bis(2-ethylhexanoate)(EC# 230-743-8) falls well within the average molecular weight range of the members of the category (637 – 1023).

 

At the slightly basic pH’s seen in aquatic systems, the hydrolysis of the pentaerythrithol esters may be limited for steric reasons, i.e. the ester groups are expected to be well shielded by the aliphatic substituents and thus not be accessible for hydrolytic degradation. Therefore it is expected that the substances will be present mainly unsplit and that the toxicity of the intact moiety needs to be considered.

 

The ability of the pentaerythrithol esters to reach the target sites in aquatic organisms will depend strongly on their solubility and their octanol-water partition coefficient. Solubility of the members of the category is in general low and the octanol-water partition coefficient is very high (EpiWin). Therefore, bioaccumulation in aquatic organisms is not favoured.

 

Based on the above considerations, it can be concluded that the eco-toxicological properties for 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]propane-1,3-diyl bis(2-ethylhexanoate)(EC# 230-743-8) can be derived directly by read-across from known esters.

 

Acute toxicity to fish (LL50) is > 100 mg/l, i.e. >> water solubility.

Acute toxicity to aquatic invertebrates (Daphnia) (EL50) is > 100 mg/l, i.e. >> water solubility.

Acute toxicity to aquatic plants (Algae) (EL50) is > 100 mg/l, i.e. >> water solubility.

At a concentration of 100 mg/l, i.e. >> water solubility, the substances are not toxic to waste water (activated sludge) bacteria.

 

As there are no effects at the limit of solubility within water, derivation of a PNEC is not applicable. All PNECS would be “greater than” values, and hence are meaningless. The substance is not hazardous to the environment.

 

Conclusion on classification

The 50% effect criterion up to the water solubility has not been reached in acute studies performed with analogue substances. Based on read-across it was concluded that the substance is not readily biodegradable. Based on this and a high log Kow, the substance does not need to be classified for the environment according to CLP.