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EC number: 918-594-3 | CAS number: 7723-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well performed guideline conform non GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Principles of method if other than guideline:
- only one group of animals has been used
a dose of 15000 mg/kg body weight has been used instead of 2000 mg/kg body weight
only female rodents were used because in prior studies sex-related differences had not been noticed - GLP compliance:
- no
- Remarks:
- study performed before GLP guidelines
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- phosphorus
- EC Number:
- 918-594-3
- Cas Number:
- 7723-14-0
- Molecular formula:
- (P)n (Phosphorus red modification)
- IUPAC Name:
- phosphorus
- Reference substance name:
- Phosphorus
- EC Number:
- 231-768-7
- EC Name:
- Phosphorus
- Cas Number:
- 7723-14-0
- IUPAC Name:
- phosphine
- Details on test material:
- - Name of test material (as cited in study report): Phosphor rot
- Substance type: element
- Physical state: powder
- Stability under test conditions: stable
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: report 131/75
- Weight at study initiation: see table below
- Fasting period before study: 16 hours
- Housing: in plastic cages on wood shavings
- Diet (e.g. ad libitum): Altromin 1324 (Altrogge)
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% starch mucilage
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 15000 mg/kg body weight
- Doses:
- one dose with 15000 mg/kg body weight
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?) 14 days
- Frequency of observations and weighing: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: clinical signs, body weight, necropsy
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 15 000 mg/kg bw
- Mortality:
- no mortality occured during the study
- Clinical signs:
- other: no clinical signs have been observed
- Gross pathology:
- No effects
Any other information on results incl. tables
body weight of the rats
Animal no. | sex | dose [mg/kg] | initally body weight | body weight after 7 days | body weight after 14 days |
1 | female | 15000 | 98 | 138 | 160 |
2 | female | 15000 | 90 | 120 | 136 |
3 | female | 15000 | 102 | 144 | 166 |
4 | female | 15000 | 94 | 128 | 150 |
5 | female | 15000 | 94 | 126 | 150 |
6 | female | 15000 | 92 | 126 | 144 |
7 | female | 15000 | 104 | 146 | 172 |
8 | female | 15000 | 96 | 124 | 142 |
9 | female | 15000 | 96 | 138 | 158 |
10 | female | 15000 | 100 | 128 | 144 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 (acute oral) of red phoshorus in female rats is > 15000 mg/kg bw.
- Executive summary:
After the administration of the highest applicable amount of 15,000 mg red phosphorus
/kg bw, the all animals survived and showed normal behavior during the 14 days observation time.The trend in body weight of the animals during the observation period is given in the table above. The necropsy of the killed animals at the end of the observation period did not reveal any macroscopically visible changes.
Based on the current results the specific acute oral toxicity could not be determined. The acute oral LD50 for female rats is for sure above 15000 mg/kg body weight.
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