Registration Dossier
Registration Dossier
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EC number: 205-746-2 | CAS number: 149-74-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- No details of a guideline and only limited details of the method are given in this brief report. A group of 5 rats was exposed to the saturated vapour for 7 hours.
- GLP compliance:
- no
- Test type:
- other:
Test material
- Reference substance name:
- Dichloro(methyl)(phenyl)silane
- EC Number:
- 205-746-2
- EC Name:
- Dichloro(methyl)(phenyl)silane
- Cas Number:
- 149-74-6
- Molecular formula:
- C7H8Cl2Si
- IUPAC Name:
- dichloro(methyl)(phenyl)silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- Unstated. Said to be saturated. Room temperature 27 deg C. No further details given.
- No. of animals per sex per dose:
- 5 (sex not stated)
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC100
- Effect level:
- other: atmosphere said to be saturated
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: death of 5/5
Any other information on results incl. tables
One animal died during the exposure. The other 4 died within one hour post-exposure.
Nasal irritation within 20 minutes followed by marked irritation to eyes.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- A very limited summary of non-guideline, non-GLP study, recorded the deaths of all five rats during or within 1 h of a 7 h exposure to an atmosphere said to be saturated with the test material.
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