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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
sub-chronic toxicity: dermal
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:

For justification of read across see category justification attached to category object.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-(2-ethoxyethoxy)ethoxy)ethanol
EC Number:
203-978-9
EC Name:
2-(2-(2-ethoxyethoxy)ethoxy)ethanol
Cas Number:
112-50-5
Molecular formula:
C8H18O4
IUPAC Name:
2-(2-(2-ethoxyethoxy)ethoxy)ethanol
Constituent 2
Reference substance name:
2-(2-(2-ethoxyyethoxy)ethoxy)ethanol
IUPAC Name:
2-(2-(2-ethoxyyethoxy)ethoxy)ethanol
Details on test material:
no data

Results and discussion

Effect levels

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Dose descriptor:
NOAEL
Effect level:
5 000 mg/kg bw/day
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: All other effects other than local irritation
Remarks on result:
other: based on a weighted average consideration of the results for this substance based on other substances within the category.
Remarks:
There is no data on the repeat dose toxicity of this substance from studies to modern guidelines. A sub-acute bridging study is being carried out on this substance to add confidence to bridging between members of this category.
Dose descriptor:
NOAEL
Effect level:
500 mg/kg bw/day
Based on:
test mat.
Sex:
male/female
Basis for effect level:
dermal irritation
Remarks on result:
other: based on a weighted average consideration of the results for this substance based on other substances within the category.
Remarks:
There is no data on the repeat dose toxicity of this substance from studies to modern guidelines. A sub-acute bridging study is being carried out on this substance to add confidence to bridging between members of this category.

Target system / organ toxicity

Critical effects observed:
no

Applicant's summary and conclusion