Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

** DTYP  DATA TYPE         MSTU; Mutagenicity Study  1 of 38              
  TSY   TEST SYSTEM       MOUSE LYMPHOMA                                  
  STIN  STRAIN/INDICATOR  L5178Y (TK+/TK-)                                
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            SUSPENSION/PLATE                                
  DOS   DOSE              2.1-4.72 UMOL/L                                 
  RES   RESULT            POSITIVE                                        
  RF    REFERENCES        WANGENHEIM,J AND BOLCSFOLDI,G, MOUSE LYMPHOMA   
                            L5178Y THYMIDINE KINASE LOCUS ASSAY OF 50       
                            COMPOUNDS, MUTAGENESIS 3(3):193-205, 1988       
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  2 of 38              
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA97                                            
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              0.125-4 UG/PLATE                                
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  3 of 38              
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA98                                            
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              0.125-4 UG/PLATE                                
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  4 of 38              
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA100                                           
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              0.125-4 UG/PLATE                                
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  5 of 38              
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA102                                           
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              0.125-4 UG/PLATE                                
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  6 of 38              
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA104                                           
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              0.125-4 UG/PLATE                                
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  7 of 38              
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA1535                                          
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              0.125-4 UG/PLATE                                
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  8 of 38              
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA97                                            
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, AROCLOR 1254                   
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              10-200 UG/PLATE                                 
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  9 of 38              
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA98                                            
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, AROCLOR 1254                   
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              10-200 UG/PLATE                                 
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  10 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA100                                           
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, AROCLOR 1254                   
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              10-200 UG/PLATE                                 
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  11 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA102                                           
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, AROCLOR 1254                   
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              10-200 UG/PLATE                                 
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  12 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA104                                           
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, AROCLOR 1254                   
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              10-200 UG/PLATE                                 
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  13 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA1535                                          
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, AROCLOR 1254                   
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              10-200 UG/PLATE                                 
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  14 of 38             
  TSY   TEST SYSTEM       CHINESE HAMSTER V-79                            
  STIN  STRAIN/INDICATOR  V-79/6-THIOGUANINE                              
  MAC   METABOLIC ACTIV.  NONE                                            
  DOS   DOSE              1.7 MICROMOLAR                                  
  RES   RESULT            POSITIVE                                        
  RF    REFERENCES        GLATT,H, PADYKULA,R, BERCHTOLD,GA, LUDEWIG,G,   
                            PLATT,KL, KLEIN,J AND OESCH,F, MULTIPLE         
                            ACTIVATION PATHWAYS OF BENZENE LEADING TO       
                            PRODUCTS WITH VARYING GENOTOXIC                 
                            CHARACTERISTICS, ENVIRON. HEALTH PERSPECT.      
                            82:81-89, 1989                                  
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  15 of 38             
  TSY   TEST SYSTEM       CHINESE HAMSTER V-79                            
  STIN  STRAIN/INDICATOR  V-79/6-THIOGUANINE                              
  MAC   METABOLIC ACTIV.  NONE                                            
  DOS   DOSE              2.5-100 MICROMOLAR (TEST MATERIAL SOLVENT:      
                            DMSO)                                           
  RES   RESULT            POSITIVE                                        
  RF    REFERENCES        LUDEWIG,G, DOGRA,S AND GLATT,H, GENOTOXICITY OF 
                            1,4-BENZOQUINONE AND 1,4-NAPHTHOQUINONE IN      
                            RELATION TO EFFECTS ON GLUTATHIONE AND NAD(P)H  
                            LEVELS IN V79 CELLS, ENVIRON. HEALTH PERSPECT.  
                            82:223-228, 1989                                
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  16 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA100                                           
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            FLUCTUATION TEST                                
  DOS   DOSE              0-5000 NG/WELL                                  
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        KIOKE,N, HAGA,S, UBUKATA,N, SAKURAI,M,          
                            SHIMIZU,H AND SATO,A, MUTAGENICITY OF BENZENE   
                            METABOLITES BY FLUCTUATION TEST, SANGYO IGAKU   
                            30(6):475-80, 1988                              
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  17 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA100                                           
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, PCB                            
  METH  METHOD            FLUCTUATION TEST                                
  DOS   DOSE              0-200 NG/WELL (TEST MATERIAL SOLVENT: DMSO)     
  RES   RESULT            POSITIVE                                        
  RF    REFERENCES        KIOKE,N, HAGA,S, UBUKATA,N, SAKURAI,M,          
                            SHIMIZU,H AND SATO,A, MUTAGENICITY OF BENZENE   
                            METABOLITES BY FLUCTUATION TEST, SANGYO IGAKU   
                            30(6):475-80, 1988                              
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  18 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA97                                            
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, PCB                            
  METH  METHOD            STANDARD PLATE                                  
  DOS   DOSE              5-250 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)    
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        SAKAI,M, YOSHIDA,D AND MIZUSAKI,S, MUTAGENICITY 
                            OF POLYCYCLIC AROMATIC HYDROCARBONS AND         
                            QUINONES ON SALMONELLA TYPHIMURIUM TA97, MUTAT. 
                            RES. 156(1-2):61-67, 1985                       
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  19 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA98                                            
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, PCB                            
  METH  METHOD            STANDARD PLATE                                  
  DOS   DOSE              5-250 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)    
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        SAKAI,M, YOSHIDA,D AND MIZUSAKI,S, MUTAGENICITY 
                            OF POLYCYCLIC AROMATIC HYDROCARBONS AND         
                            QUINONES ON SALMONELLA TYPHIMURIUM TA97, MUTAT. 
                            RES. 156(1-2):61-67, 1985                       
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  20 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA100                                           
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, PCB                            
  METH  METHOD            STANDARD PLATE                                  
  DOS   DOSE              5-250 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)    
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        SAKAI,M, YOSHIDA,D AND MIZUSAKI,S, MUTAGENICITY 
                            OF POLYCYCLIC AROMATIC HYDROCARBONS AND         
                            QUINONES ON SALMONELLA TYPHIMURIUM TA97, MUTAT. 
                            RES. 156(1-2):61-67, 1985                       
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  21 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA97                                            
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            STANDARD PLATE                                  
  DOS   DOSE              5-250 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)    
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        SAKAI,M, YOSHIDA,D AND MIZUSAKI,S, MUTAGENICITY 
                            OF POLYCYCLIC AROMATIC HYDROCARBONS AND         
                            QUINONES ON SALMONELLA TYPHIMURIUM TA97, MUTAT. 
                            RES. 156(1-2):61-67, 1985                       
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  22 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA98                                            
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            STANDARD PLATE                                  
  DOS   DOSE              5-250 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)    
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        SAKAI,M, YOSHIDA,D AND MIZUSAKI,S, MUTAGENICITY 
                            OF POLYCYCLIC AROMATIC HYDROCARBONS AND         
                            QUINONES ON SALMONELLA TYPHIMURIUM TA97, MUTAT. 
                            RES. 156(1-2):61-67, 1985                       
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  23 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA100                                           
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            STANDARD PLATE                                  
  DOS   DOSE              5-250 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)    
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        SAKAI,M, YOSHIDA,D AND MIZUSAKI,S, MUTAGENICITY 
                            OF POLYCYCLIC AROMATIC HYDROCARBONS AND         
                            QUINONES ON SALMONELLA TYPHIMURIUM TA97, MUTAT. 
                            RES. 156(1-2):61-67, 1985                       
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  24 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA97                                            
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              5-20 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)     
  RES   RESULT            POSITIVE                                        
  RF    REFERENCES        LIN,JK AND LEE,SF, ENHANCEMENT OF THE           
                            MUTAGENICITY OF POLYPHENOLS BY CHLORINATION AND 
                            NITROSATION IN SALMONELLA TYPHIMURIUM, MUTAT.   
                            RES. 269(2): 217-224, 1992                      
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  25 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA98                                            
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              5-20 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)     
  RES   RESULT            POSITIVE                                        
  RF    REFERENCES        LIN,JK AND LEE,SF, ENHANCEMENT OF THE           
                            MUTAGENICITY OF POLYPHENOLS BY CHLORINATION AND 
                            NITROSATION IN SALMONELLA TYPHIMURIUM, MUTAT.   
                            RES. 269(2): 217-224, 1992                      
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  26 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA97                                            
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, PHENOBARBITAL                  
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              5-20 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)     
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        LIN,JK AND LEE,SF, ENHANCEMENT OF THE           
                            MUTAGENICITY OF POLYPHENOLS BY CHLORINATION AND 
                            NITROSATION IN SALMONELLA TYPHIMURIUM, MUTAT.   
                            RES. 269(2): 217-224, 1992                      
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  27 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA98                                            
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, PHENOBARBITAL                  
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              5-20 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)     
  RES   RESULT            POSITIVE                                        
  RF    REFERENCES        LIN,JK AND LEE,SF, ENHANCEMENT OF THE           
                            MUTAGENICITY OF POLYPHENOLS BY CHLORINATION AND 
                            NITROSATION IN SALMONELLA TYPHIMURIUM, MUTAT.   
                            RES. 269(2): 217-224, 1992                      
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  28 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA100                                           
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, PHENOBARBITAL                  
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              5-20 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)     
  RES   RESULT            POSITIVE                                        
  RF    REFERENCES        LIN,JK AND LEE,SF, ENHANCEMENT OF THE           
                            MUTAGENICITY OF POLYPHENOLS BY CHLORINATION AND 
                            NITROSATION IN SALMONELLA TYPHIMURIUM, MUTAT.   
                            RES. 269(2): 217-224, 1992                      
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  29 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA100                                           
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              5-20 UG/PLATE (TEST MATERIAL SOLVENT: DMSO)     
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        LIN,JK AND LEE,SF, ENHANCEMENT OF THE           
                            MUTAGENICITY OF POLYPHENOLS BY CHLORINATION AND 
                            NITROSATION IN SALMONELLA TYPHIMURIUM, MUTAT.   
                            RES. 269(2): 217-224, 1992                      
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  30 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA98                                            
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        HAKURA,A, MOCHIDA,H, TSUTSUI,Y AND YAMATSU,K,   
                            MUTAGENICITY OF BENZOQUINONES FOR AMES          
                            SALMONELLA TESTER STRAINS, MUTAT. RES.          
                            347(1):37-43, 1994                              
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  31 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA98                                            
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, PHENOBARBITAL AND              
                            5,6-BENZOFLAVONE                                
  METH  METHOD            PREINCUBATION                                   
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        HAKURA,A, MOCHIDA,H, TSUTSUI,Y AND YAMATSU,K,   
                            MUTAGENICITY OF BENZOQUINONES FOR AMES          
                            SALMONELLA TESTER STRAINS, MUTAT. RES.          
                            347(1):37-43, 1994                              
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  32 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA2637                                          
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        HAKURA,A, MOCHIDA,H, TSUTSUI,Y AND YAMATSU,K,   
                            MUTAGENICITY OF BENZOQUINONES FOR AMES          
                            SALMONELLA TESTER STRAINS, MUTAT. RES.          
                            347(1):37-43, 1994                              
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  33 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA2637                                          
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, PHENOBARBITAL AND              
                            5,6-BENZOFLAVONE                                
  METH  METHOD            PREINCUBATION                                   
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        HAKURA,A, MOCHIDA,H, TSUTSUI,Y AND YAMATSU,K,   
                            MUTAGENICITY OF BENZOQUINONES FOR AMES          
                            SALMONELLA TESTER STRAINS, MUTAT. RES.          
                            347(1):37-43, 1994                              
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  34 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA102                                           
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        HAKURA,A, MOCHIDA,H, TSUTSUI,Y AND YAMATSU,K,   
                            MUTAGENICITY OF BENZOQUINONES FOR AMES          
                            SALMONELLA TESTER STRAINS, MUTAT. RES.          
                            347(1):37-43, 1994                              
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  35 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA102                                           
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, PHENOBARBITAL AND              
                            5,6-BENZOFLAVONE                                
  METH  METHOD            PREINCUBATION                                   
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        HAKURA,A, MOCHIDA,H, TSUTSUI,Y AND YAMATSU,K,   
                            MUTAGENICITY OF BENZOQUINONES FOR AMES          
                            SALMONELLA TESTER STRAINS, MUTAT. RES.          
                            347(1):37-43, 1994                              
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  36 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA100                                           
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        HAKURA,A, MOCHIDA,H, TSUTSUI,Y AND YAMATSU,K,   
                            MUTAGENICITY OF BENZOQUINONES FOR AMES          
                            SALMONELLA TESTER STRAINS, MUTAT. RES.          
                            347(1):37-43, 1994                              
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  37 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA104                                           
  MAC   METABOLIC ACTIV.  RAT, LIVER, S-9, PHENOBARBITAL AND              
                            5,6-BENZOFLAVONE                                
  METH  METHOD            PREINCUBATION                                   
  RES   RESULT            NEGATIVE                                        
  RF    REFERENCES        HAKURA,A, MOCHIDA,H, TSUTSUI,Y AND YAMATSU,K,   
                            MUTAGENICITY OF BENZOQUINONES FOR AMES          
                            SALMONELLA TESTER STRAINS, MUTAT. RES.          
                            347(1):37-43, 1994                              
                                                                             
** DTYP  DATA TYPE         MSTU; Mutagenicity Study  38 of 38             
  TSY   TEST SYSTEM       AMES SALMONELLA TYPHIMURIUM                     
  STIN  STRAIN/INDICATOR  TA104                                           
  MAC   METABOLIC ACTIV.  NONE                                            
  METH  METHOD            PREINCUBATION                                   
  DOS   DOSE              0-22 NMOL/PLATE (TEST MATERIAL SOLVENT: DMSO)   
  RES   RESULT            POSITIVE                                        
  RF    REFERENCES        HAKURA,A, MOCHIDA,H, TSUTSUI,Y AND YAMATSU,K,   
                            MUTAGENICITY OF BENZOQUINONES FOR AMES          
                            SALMONELLA TESTER STRAINS, MUTAT. RES.          
                            347(1):37-43, 1994                              


Endpoint Conclusion:

Justification for classification or non-classification

Indication of genotoxicity in vitro available.