Registration Dossier
Registration Dossier
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EC number: 204-596-5 | CAS number: 123-05-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication, meets scientific background and is sufficient for endpoint evaluation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Salmonella Mutagenicity Tests : IV. Results , From the Testing of 300 Chemicals
- Author:
- Zeiger E. et al.
- Year:
- 1 988
- Bibliographic source:
- Environ. Molec. Mut., Vol. 11, Suppl. 12, 1-158 (1988)
Materials and methods
- Principles of method if other than guideline:
- Method: other. Testing of 300 chemicals for their ability to induce mutations in strains of Salmonella typhimuriurn. The rationale for testing has been described in detail elsewhere [Zeiger and Drake, 1980].
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-ethylhexanal
- EC Number:
- 204-596-5
- EC Name:
- 2-ethylhexanal
- Cas Number:
- 123-05-7
- Molecular formula:
- C8H16O
- IUPAC Name:
- 2-ethylhexanal
- Details on test material:
- - Name of test material (as cited in study report): 2-Ethylhexanal
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Sal. typh. TA 97, 98, 100, 1535, 1537
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9-mix
- Test concentrations with justification for top dose:
- 3 - 666 ug/plate
- Details on test system and experimental conditions:
- IUCLID4 Type: Ames test
Results and discussion
Test results
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks on result:
- other: other: Sal. typh. TA 97, 98, 100, 1535, 1537
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
