Registration Dossier

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Methacrylic acid and derivatives
Author:
Nemec JW, Kirch LS
Year:
1981
Bibliographic source:
Kirk-Othmer, Encyclopedia of chemical technology, 3rd edition, Volume 15, p 346-376

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Reference substance name:
1-methyltrimethylene dimethacrylate
EC Number:
214-711-0
EC Name:
1-methyltrimethylene dimethacrylate
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): 1,3-butylene dimethacrylate

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: CLP, EU GHS (Regulation (EC) No 1272/2008)
Conclusions:
The acute dermal LD50 of 1,3-BDDMA is reported to be >3000 mg/kg bw in rabbit.
Executive summary:

The acute dermal LD50 of 1,3-BDDMA is reported to be >3000 mg/kg bw in rabbit.