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Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Reason / purpose for cross-reference:
reference to same study
no guideline followed
not specified
Principles of method if other than guideline:
Excess recrystallized p-aminophenol was added to previously boiled distilled water ( to expel dissolved oxygen) in a 200 ml flask placed in a thermostated oil-bath. The system was again boiled by evacuation ( to remove oxygen in the vapor phase), sealed off and allowed to equilibrate with occasional hand agitation. Samples were taken in a tared pipet and weighed, and the amine content was determined by the nitrate procedure.
GLP compliance:
not specified
Type of method:
flask method
Water solubility:
ca. 0.6 - ca. 0.65 other: weight %
25 °C
Remarks on result:
other: solubility increases with temperature

Additional values based on temperature gradient graph:

0.39% @ 13 C;

0.80 % @ 30 C;

1.5% @ 50 C;

4.7% @ 80 C

Interpretation of results (migrated information): soluble (1000-10000 mg/L)
Substance is soluble in water at 0.65% at 24 C.

Description of key information

Water solubility at 0.65% at 24C (6500 mg/l)

Key value for chemical safety assessment

Water solubility:
6 500 mg/L
at the temperature of:
25 °C

Additional information

One key study was included from a published study and three supporting endpoint records all from well known reference manuals.

The key study result from experimental data from literature was reported as 0.65% at 24C ( 6500 mg/L). This was referenced in a secondary supporting study also.. Two other supporting studies from secondary reference manuals reported water solubility as 11,000 mg/L at 0C and 15.75 g/L at 20C. All values fall into the soluble or very soluble range. It is concluded that based on this data that 4 -aminophenol is soluble in water.